Bernd Kaina

from Wikipedia, the free encyclopedia

Bernd Kaina (born January 7, 1950 in Drewitz , Niederlausitz ) is a German biologist and toxicologist . His research interests are DNA damage and repair , the DNA damage response as well as genotoxic signaling and cell death induced by carcinogenic noxae.

Life

Kaina studied biology at the University of Halle . Here he did his doctorate with a thesis on the effects of the neurotropic carcinogen nitrosomethylurea on human cells. From 1975 to 1984 he was project manager at the Central Institute for Genetics and Crop Plant Research in Gatersleben , where he dealt with the genotoxic effects of alkylating agents on various experimental systems. In 1984 he moved with his family from the GDR to the West , first received an EG scholarship at the Institute for Molecular Biology in Leiden and then, from 1985 to 1987, worked as a visiting scientist at the German Cancer Research Center in Heidelberg . As a Heisenberg fellow from the DFG, he went to the Institute for Genetics and Toxicology of Fissile Materials at the Karlsruhe Nuclear Research Center . From there he was appointed as C3 professor and head of the department for applied toxicology at the Institute for Toxicology at the University of Mainz . He did not accept a call for a C4 professorship at the University of Göttingen. He has been a C4 professor since 2004 and was director of the Institute for Toxicology at the University Medical Center at Johannes Gutenberg University Mainz until 2018 .

plant

Kaina made fundamental contributions to the understanding of the effects of alkylating carcinogens and cancer chemotherapeutic agents. In particular, he highlighted the importance of DNA repair as a factor in drug resistance in glioblastomas, malignant melanomas and other types of tumors and identified the repair enzyme MGMT as a protective mechanism against alkylating carcinogens. He made a major contribution to the understanding of the mutagenic and cytotoxic effects of UV light, ionizing radiation and chemical genotoxins and showed that DNA repair genes can be induced after genotoxic stress, which contributes to cellular protection. His bibliography includes more than 250 articles in international journals and books.

Awards

  • Heisenberg fellow of the German Research Foundation
  • Research Award of the German Society for Environmental Mutagenesis (2009)
  • German Cancer Prize , experimental part (2011)
  • Toxicology Award of the German Society for Experimental and Clinical Pharmacology and Toxicology (2012)
  • Ulrich Hagen Prize of the Society for Biological Radiation Research (2014)

Fonts (selection)

  • Christmann M., M. Tomicic-Christmann, WP Roos and B. Kaina (2003): Mechanisms of human DNA repair - an update. In: Toxicology . Vol. 193, pp. 3-34, PMID 14599765 .
  • Kaina B. (2004): Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go. In: Cytogenet. Genome Res. Vol. 104, pp. 77-86, PMID 15162018 .
  • Roos WP and B. Kaina (2006): DNA damage-induced cell death by apoptosis. In: Trends Mol. Medicine. Vol. 12, pp. 440-450, PMID 16899408 .
  • Kaina B., M. Christmann, S. Naumann and WP. Roos (2007): MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. In: DNA Repair . Vol. 6, pp. 1079-1099, PMID 17485253 .
  • Kaina B., G. Margison and M. Christmann (2010): Targeting O6-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy. In: Cell. Mol. Life Sci. Vol. 67, pp. 3663-3681, PMID 20717836 .
  • Kaina, B. and M. Christmann (2011): DNA damage response and its pharmacological influence. In: The oncologist. Vol. 6, pp. 503-512, DOI: 10.1007 / s00761-011-2028-6 .
  • Roos, WP and B. Kaina (2013): DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis. In: Cancer Letters . Vol. 332, pp. 237-248, PMID 22261329 .
  • Roos WP, Thomas A., and B. Kaina (2016): DNA damage and the balance between survival and death in cancer biology. In: Nature Rev. Cancer. Vol. 16, pp. 20-33, PMID 26678314 .

literature

Individual evidence

  1. ↑ Bernd Kaina's curriculum vitae on the Mainz University Medical Center website, accessed on July 13, 2016.
  2. ↑ Bernd Kaina's list of publications in Pubmed , accessed on July 13, 2016.
personal data
SURNAME Kaina, Bernd
BRIEF DESCRIPTION German biologist and toxicologist
DATE OF BIRTH January 7, 1950
PLACE OF BIRTH Drewitz , Lower Lusatia