Bronidox

Structural formula
General
Surname	Bronidox
Molecular formula	C 4 H 6 BrNO 4
Brief description	almost colorless crystals
External identifiers / databases
CAS number 30007-47-7 EC number 250-001-7 ECHA InfoCard 100.045.441 PubChem 1807 Wikidata Q4973879
properties
Molar mass	212.00 g mol −1
Physical state	firmly
Melting point	58-60 ° C
boiling point	Decomposition from 113–116 ° C (17 hPa )
solubility	hardly soluble in water (4.6 g l −1 at 20 ° C)
safety instructions
GHS labeling of hazardous substances danger H and P phrases H: 302-314-410 P: 260-280-301 + 312 + 330-303 + 361 + 353-304 + 340 + 310-305 + 351 + 338
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Bronidox ( 5-bromo-5-nitro-1,3-dioxane ) is a chemical compound from the group of 1,3-dioxanes that is bacteriostatic .

Bronidox is therefore suitable as a preservative for cosmetics and is one of the most frequently used active ingredients.

The compound is metabolized to bronopol , 2-nitropropanediol and 2-nitroethanol .

Inhibition values ​​in ppm

	Bronidox	formaldehyde	PHB ester
Escherichia coli	50	60	800
Pseudomonas aeruginosa	50	125	800
Staphylococcus aureus	75	60	500
Kocuria varians	25th	-	-
Candida albicans	25th	250	800
Aspergillus niger	10	250	250

Individual evidence

1. ↑ ^{a b c} Entry on 5-bromo-5-nitro-1,3-dioxane. In: Römpp Online . Georg Thieme Verlag, accessed on November 7, 2015.
2. ↑ ^{a b c d} M. Potokar, W. Greb, H. Ippen, HI Maibach, KH Schulz, P. Lorenz, Chr. Gloxhuber: Bronidox, a new preservative for cosmetics . Properties and toxicological-dermatological test results. In: fats, soaps, paints . tape 78 , no. 7 , 1976, p. 269-276 , doi : 10.1002 / lipi.19760780703 ( PDF ).
3. ↑ ^{a b} Data sheet 5-Bromo-5-nitro-1,3-dioxane, ≥99% from Sigma-Aldrich , accessed on May 30, 2017 ( PDF ).