COL21A1
| Collagen type XXI, alpha 1 | ||
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| other names |
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| Properties of human protein | ||
| Mass / length primary structure | 957 amino acids , 99,369 Da | |
| Isoforms | 3 | |
| Identifier | ||
| Gene names | COL21A1; FP633 | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Opisthokonta | |
| Orthologue (human) | ||
| Entrez | 81578 | |
| Ensemble | ENSG00000124749 | |
| UniProt | Q96P44 | |
| Refseq (mRNA) | NM_030820 | |
| Refseq (protein) | NP_110447.2 | |
| Gene locus | Chr 6: 56.06 - 56.39 Mb | |
| PubMed search |
81578
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Collagen type XXI, alpha 1 is a fibrillenassoziiertes collagen that the gene COL21A1 is encoded. It forms homotrimers , which in turn form collagen fibrils of type XXI.
properties
Collagen type XXI, alpha 1 is an extracellular matrix component of the blood vessel wall that is produced by smooth muscle cells. The platelet-derived growth factor stimulates the expression of COL21A1 in cultured, aortic smooth muscle cells. Collagen XXI may contribute to the formation of the extracellular matrix of the vascular network during vasculogenesis .
In Drosophila melanogaster , the enzyme prolyl-4-hydroxylase trimerizes collagen XXI, which contains the intact C -terminal non-collagenous (NC1) and collagenous domains (COL1).
Web links
Individual evidence
- ↑ Min-Yuan Chou, Hsiu-Chuan Li: Genomic organization and characterization of the human type XXI collagen (COL21A1) gene . In: Genomics . 79, No. 3, March 2002, pp. 395-401. doi : 10.1006 / geno.2002.6712 . PMID 11863369 .
- ↑ Hsiu-Chuan Li, Chuan-Chuan Huang, Sung-Fang Chen, Min-Yuan Chou: Assembly of homotrimeric type XXI minicollagen by coexpression of prolyl 4-hydroxylase in stably transfected Drosophila melanogaster S2 cells . In: Biochem Biophys Res Commun . 336, No. 2, October 21, 2005, pp. 375-385. doi : 10.1016 / j.bbrc.2005.08.018 . PMID 16115607 .