COL22A1

Collagen type XXII, alpha 1
other names	Alpha 1 type XXII collagen Collagen Alpha-1 (XXII) chain Collagen alpha-1 chain type XXII
Properties of human protein
Mass / length primary structure	1,125 amino acids , 116,657 Da
Isoforms	3
Identifier
Gene name	COL22A1
External IDs	GeneCards :  COL22A1 OMIM :  610026 UniProt :  Q8NFW1 MGI :  1916950
Occurrence
Parent taxon	Amniota , Clupeocephala
Orthologue
	human	House mouse
Entrez	169044	69700
Ensemble	ENSG00000169436	ENSMUSG00000079022
UniProt	Q8NFW1
Refseq (mRNA)	NM_152888	NM_027174
Refseq (protein)	NP_690848.1
Gene locus	Chr 8: 138.59 - 138.91 Mb	Chr 15: 71.8 - 72.03 Mb
PubMed search	169044	69700

Collagen type XXII, alpha 1 is a fibrillenassoziiertes collagen that the gene COL22A1 is encoded. It forms homotrimers , which in turn form collagen fibrils of type XXII.

properties

Collagen type XXII, alpha 1 is expressed on the myotendinous junction and on the articular surface of the cartilage tissue . Collagen XXII participates in the cell adhesion of ligands in multilayered epithelia and in fibroblasts .

Web links

• MeSH COL22A1

Individual evidence

1. ↑ Daniela Zwolanek, Guido Veit, Johannes A. Eble, Donald Gullberg, Florence Ruggiero, Jyrki Heino, Markus Meier, Jörg Stetefeld, Manuel Koch: Collagen XXII binds to collagen-binding integrins via the novel motifs GLQGER and GFKGER . In: Biochem J . 459, No. 1, April 1, 2014, pp. 217-227. doi : 10.1042 / BJ20130642 . PMID 24428702 .
2. ↑ Manuel Koch, Joerg Schulze, Uwe Hansen, Todd Ashwodt, Douglas R. Keene, William J. Brunken, Robert E. Burgeson, Peter Bruckner, Leena Bruckner-Tuderman: A Novel Marker of Tissue Junctions, Collagen XXII . In: J Biol Chem . 279, No. 21, May 21, 2004, pp. 22514-22521. doi : 10.1074 / jbc.M400536200 . PMID 15016833 . PMC 2925840 (free full text).