COL26A1

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Collagen type XXVI, alpha 1
other names
  • Alpha-1 type XXVI collagen
  • Collagen Alpha-1 (XXVI) chain
  • Collagen alpha-1 chain type XXVI

Existing structure data : PDB  4AU2 , PDB  4AU3 , PDB  4BJ3

Properties of human protein
Mass / length primary structure 441 amino acids , 45,381 Da
Isoforms 2
Identifier
Gene names COL26A1; EMID2; EMU2; EMI6; SH2B
External IDs
Occurrence
Parent taxon Sarcopterygii
Orthologue
human House mouse
Entrez 136227 140709
Ensemble ENSG00000160963 ENSMUSG00000004415
UniProt Q96A83 Q91VF6
Refseq (mRNA) NM_133457 NM_024474
Refseq (protein) NP_001265492.1 NP_077794.2
Gene locus Chr 7: 101.36 - 101.56 Mb Chr 5: 136.74 - 136.88 Mb
PubMed search 136227 140709

Collagen type XXVI, alpha 1 is a collagen that the gene COL26A1 is encoded. It forms homotrimers , which in turn form collagen fibrils of type XXVI.

properties

Type XXV, alpha 1 collagen contains an emilin domain and two collagen segments. It is in the testes and the ovaries expressed . The collagenase 5-benzamido-4-hydroxy-6-phenylhexanoyl-Pro-Ala (XXVI) is in Clostridium histolyticum by aldehyde - and ketone - substrate analogues inhibited.

COL26A1 is often associated with the formation of nasal polyps in the nasal cavity .

Web links

Individual evidence

  1. ↑ Keiji Sato, Kentaro Yomogida, Takayuki Wada, Tetuya Yorihuzi, Yoshitake Nishimune, Nobuko Hosokawa, Kazuhiro Nagata: Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary . In: J Biol Chem . 277, No. 40, October 4, 2002, pp. 37678-37684. doi : 10.1074 / jbc.M205347200 . PMID 12145293 .
  2. ↑ D. Grobelny, RE Galardy: Aldehyde and ketone substrate analogues inhibit the collagenase of Clostridium histolyticum . In: Biochemistry . 24, No. 22, October 22, 1985, pp. 6145-6152. PMID 3002433 .
  3. ↑ Charisse Flerida Arnejo Pasaje, Joon Seol Bae, Byung-Lae Park, Hyun Sub Cheong, Jeong-Hyun Kim, An-Soo Jang, Soo-Taek Uh, Choon-Sik Park, Hyoung Doo Shin: Possible role of EMID2 on nasal polyps pathogenesis in Korean asthma patients . In: BMC Med Genet . 13, No. 2, January 4, 2012. doi : 10.1186 / 1471-2350-13-2 . PMID 22217332 . PMC 3398310 (free full text).