COL8A1
| Type VIII collagen, alpha 1 | ||
|---|---|---|
|
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| other names |
Endothelial collagen |
|
| Properties of human protein | ||
| Mass / length primary structure | 744 amino acids , 73,364 Da | |
| Identifier | ||
| Gene names | COL8A1 C3orf7 | |
| External IDs | ||
| Orthologue | ||
| human | House mouse | |
| Entrez | 1295 | 12837 |
| Ensemble | ENSG00000144810 | ENSMUSG00000068196 |
| UniProt | P27658 | Q00780 |
| Refseq (mRNA) | NM_001850 | NM_007739 |
| Refseq (protein) | NP_001841 | NP_031765 |
| Gene locus | Chr 3: 99.64 - 99.8 Mb | Chr 16: 57.62 - 57.75 Mb |
| PubMed search | 1295 |
12837
|
Collagen type VIII, alpha 1 is a structural protein which, alone or with the related collagen type VIII, alpha 2, forms trimers , which in turn form collagen fibrils of type VIII. Such collagen fibrils are crucial for the stability of endothelial cells in blood vessels, for the Descemet membrane of the cornea and for the cell proliferation and migration of smooth muscle cells of the blood vessels.
Clinical significance
The gene expression of COL8A1 in hepatocellular carcinomas of the mouse correlates with increased tumor cell proliferation, invasion , tumor promotion in vivo and a reduced sensitivity to anti-tumor agents. COL8A1 could thus serve as a new target for tumor therapy.
In cattle it comes through EGR1 ( English early growth response protein 1 ) for positive regulation of the expression of COL8A1, which in turn the cell proliferation of satellite cells in muscles via the PI3K / Akt pathway promoted.
Web links
Individual evidence
- ↑ UniProt P27658
- ↑ ZH Ma, JH Ma, L. Jia, YF Zhao: Effect of enhanced expression of COL8A1 on lymphatic metastasis of hepatocellular carcinoma in mice. In: Experimental and therapeutic medicine. Volume 4, number 4, October 2012, pp. 621-626, doi : 10.3892 / etm.2012.652 , PMID 23170115 , PMC 3501407 (free full text).
- ^ X. Li, Z. Wang, H. Tong, Y. Yan, S. Li: Effects of COL8A1 on the proliferation of muscle-derived satellite cells. In: Cell biology international. Volume 42, Number 9, September 2018, pp. 1132–1140, doi : 10.1002 / cbin.10979 , PMID 29696735 .