Cafedrin

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Structural formula
Structure of cafedrin
General
Non-proprietary name Cafedrin
other names
  • 7- {2 - [(α S , β R ) -β-Hydroxy-α-methylphenethylamino] ethyl} -1,3-dimethylpurine-2,6-dione
  • 7- {2 - [(1-hydroxy-1-phenylpropan-2-yl) amino] ethyl} -1,3-dimethyl-3,7-dihydro-1 H -purine-2,6-dione
  • 7- [2- (2-Hydroxy-1-methylphenethylamino) ethyl] theophylline
Molecular formula C 18 H 23 N 5 O 3
External identifiers / databases
CAS number 58166-83-9
PubChem 5489638
ChemSpider 4590188
DrugBank DB12926
Wikidata Q5017121
Drug information
ATC code

C01 CA21

Drug class

Antihypotonic

Mechanism of action

β-adrenoceptor agonist

properties
Molar mass 357.41 g mol −1
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
Pictogram unknown
H and P phrases H: ?
EUH: ?
P: ?
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Cafedrin is a drug that is used in fixed combination with theodrenaline for the parenteral treatment of a clinically relevant anesthesia-related drop in blood pressure , especially in emergency medicine .

Cafedrin acts as a stimulant on the β-adrenoceptor , which increases the heartbeat and cardiac output (CO). The effect starts slowly. The plasma half-life is 1 hour. The metabolism produces norephedrine as the main metabolite and various secondary metabolites.

Cafedrine hydrochloride is used pharmaceutically .

literature

G. Geisslinger et al .: Mutschler drug effects . 11th edition. WVG, Stuttgart 2019, p. 395.

Individual evidence

  1. ↑ Product information Akrinor 200 mg / 2 ml + 10 mg / 2 ml injection solution (ratiopharm GmbH), as of August 2019.
  2. ↑ External identifiers or database links for cafedrine hydrochloride: CAS number: 3039-97-2, EC number: 221-243-0, ECHA InfoCard: 100.019.313 , PubChem : 5492688 , ChemSpider : 4591109 , Wikidata : Q27282554 . Molecular formula: C 18 H 24 ClN 5 O 3 . Molar mass: 393.87 g mol −1 .