Cefroxadine
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Non-proprietary name | Cefroxadine | |||||||||||||||||||||
other names |
(6 R , 7 R ) -7 (( R ) -2-Amino-2- (cyclohexa-1,4-dien-1-yl) acetamido) -3-methoxy-8-oxo-5-thia-1- azabicyclo [4.2.0] oct-2-en-2-carboxylic acid ( IUPAC ) |
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Molecular formula | C 16 H 19 N 3 O 5 S | |||||||||||||||||||||
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Mechanism of action |
Disturbance of cell wall synthesis |
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properties | ||||||||||||||||||||||
Molar mass | 365.4 g mol −1 | |||||||||||||||||||||
Physical state |
firmly |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Cefroxadine is an antibiotic that is used to treat bacterial infections . It is a semisynthetic antibiotic from the class of cephalosporins of the 1st generation.
This antibiotic was used in Italy, but has since been withdrawn.
indication
Cefroxadine is a derivative of a 7-amino-cephalospranic acid (7-ACA) and is therefore structurally related to cefalexin . These two cephalosporins share a similar spectrum of activity, but differ in that cefadroxin is more effective against Escherichia coli and against Klebsiella pneumoniae .
Cefroxadine is commonly used to treat bacterial infections.
Working principle
The cefroxadine molecules bind to specific penicillin- binding proteins , which are located in the bacterial cell wall. This prevents further synthesis of the bacterial cell wall.
80–96% of the antibiotic is excreted in the urine.
Application
The antibiotic is given orally.
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ a b c d Entry on Cefroxadine in the DrugBank of the University of Alberta , accessed May 22, 2019.
- ↑ K. Yasuda, S. Kurashige, S. Mitsuhashi: Cefroxadine (CGP-9000), an Orally Active Cephalosporin . In: Antimicrobial Agents and Chemotherapy . tape 18 , no. 1 , 1980, p. 105-110 , doi : 10.1128 / AAC.18.1.105 .