Cefroxadine

Structural formula
General
Non-proprietary name	Cefroxadine
other names	(6 R , 7 R ) -7 (( R ) -2-Amino-2- (cyclohexa-1,4-dien-1-yl) acetamido) -3-methoxy-8-oxo-5-thia-1- azabicyclo [4.2.0] oct-2-en-2-carboxylic acid ( IUPAC )
Molecular formula	C 16 H 19 N 3 O 5 S
External identifiers / databases
EC number	257-391-8
ECHA InfoCard	100.052.157
PubChem	5284529
ChemSpider	4447587
DrugBank	DB11367
Wikidata	Q5057294
Drug information
ATC code	J01 DB11
Drug class	β-lactam antibiotic; Cephalosporin of the XXX. generation;
Mechanism of action	Disturbance of cell wall synthesis
properties
Molar mass	365.4 g mol −1
Physical state	firmly
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Cefroxadine is an antibiotic that is used to treat bacterial infections . It is a semisynthetic antibiotic from the class of cephalosporins of the 1st generation.

This antibiotic was used in Italy, but has since been withdrawn.

indication

Cefroxadine is a derivative of a 7-amino-cephalospranic acid (7-ACA) and is therefore structurally related to cefalexin . These two cephalosporins share a similar spectrum of activity, but differ in that cefadroxin is more effective against Escherichia coli and against Klebsiella pneumoniae .

Structure of 7-ACA

Cefroxadine is commonly used to treat bacterial infections.

Working principle

The cefroxadine molecules bind to specific penicillin- binding proteins , which are located in the bacterial cell wall. This prevents further synthesis of the bacterial cell wall.

80–96% of the antibiotic is excreted in the urine.

Application

The antibiotic is given orally.

Individual evidence

↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ ^a ^b ^c ^d Entry on Cefroxadine in the DrugBank of the University of Alberta , accessed May 22, 2019.
↑ K. Yasuda, S. Kurashige, S. Mitsuhashi: Cefroxadine (CGP-9000), an Orally Active Cephalosporin . In: Antimicrobial Agents and Chemotherapy . tape 18 , no. 1 , 1980, p. 105-110 , doi : 10.1128 / AAC.18.1.105 .

[NV-1] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[DrugBank-2] Entry on Cefroxadine in the DrugBank of the University of Alberta , accessed May 22, 2019.

[3] K. Yasuda, S. Kurashige, S. Mitsuhashi: Cefroxadine (CGP-9000), an Orally Active Cephalosporin . In: Antimicrobial Agents and Chemotherapy . tape 18 , no. 1 , 1980, p. 105-110 , doi : 10.1128 / AAC.18.1.105 .