Cethromycin
Structural formula | |||||||||||||
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General | |||||||||||||
Non-proprietary name | Cethromycin | ||||||||||||
other names |
(1 S , 2 R , 5 R , 7 R , 8 R , 9 S , 11 R , 13 R , 14 R ) -8 - [(2 S , 3 R , 4 S , 6 R ) -4-dimethylamino- 3-hydroxy-6-methyloxan-2-yl] oxy-2-ethyl-1,5,7,9,11,13-hexamethyl-9 - [( E ) -3-quinolin-3-ylprop-2-enoxy ] -3,17-dioxa-15-azabicyclo [12.3.0] heptadecane-4,6,12,16-tetron ( IUPAC ) |
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Molecular formula | C 42 H 59 N 3 O 10 | ||||||||||||
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Drug information | |||||||||||||
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properties | |||||||||||||
Molar mass | 765.93 g · mol -1 | ||||||||||||
Physical state |
firmly |
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Melting point |
211-213 ° C |
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safety instructions | |||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Cethromycin is a glycoside and antibiotic belonging to the ketolide group . It inhibits protein synthesis in bacteria. Cethromycin is currently in phase III clinical trials (Abbott) and is intended to be used against infections of the respiratory tract, e.g. B. against Streptococcus pneumoniae .
pharmacology
Cethromycin inhibits bacterial protein synthesis by binding to the 50S subunit of the ribosomes . It interferes with the 23S rRNA of this subunit by binding to domains II and V. In addition, the formation of the 30S and 50S subunits is inhibited.
literature
- RR Reinert: Clinical efficacy of ketolides in the treatment of respiratory tract infections. In: The Journal of antimicrobial chemotherapy. Volume 53, Number 6, June 2004, pp. 918-927, doi : 10.1093 / jac / dkh169 , PMID 15117934 (review).
- JE Conte, JA Golden, J. Kipps, E. Zurlinden: Steady-state plasma and intrapulmonary pharmacokinetics and pharmacodynamics of cethromycin. In: Antimicrobial agents and chemotherapy. Volume 48, number 9, September 2004, pp. 3508-3515, doi : 10.1128 / AAC.48.9.3508-3515.2004 , PMID 15328118 , PMC 514776 (free full text).
Individual evidence
- ^ The Merck Index. An Encyclopaedia of Chemicals, Drugs and Biologicals . 14th edition, 2006, p. 333, ISBN 978-0-911910-00-1 .
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.