Cethromycin

Structural formula
General
Non-proprietary name	Cethromycin
other names	(1 S , 2 R , 5 R , 7 R , 8 R , 9 S , 11 R , 13 R , 14 R ) -8 - [(2 S , 3 R , 4 S , 6 R ) -4-dimethylamino- 3-hydroxy-6-methyloxan-2-yl] oxy-2-ethyl-1,5,7,9,11,13-hexamethyl-9 - [( E ) -3-quinolin-3-ylprop-2-enoxy ] -3,17-dioxa-15-azabicyclo [12.3.0] heptadecane-4,6,12,16-tetron ( IUPAC )
Molecular formula	C 42 H 59 N 3 O 10
External identifiers / databases
CAS number 205110-48-1 PubChem 5282045 ChemSpider 34991522 Wikidata Q1057705
Drug information
Drug class	antibiotic
properties
Molar mass	765.93 g · mol -1
Physical state	firmly
Melting point	211-213 ° C
safety instructions
GHS hazard labeling no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Cethromycin is a glycoside and antibiotic belonging to the ketolide group . It inhibits protein synthesis in bacteria. Cethromycin is currently in phase III clinical trials (Abbott) and is intended to be used against infections of the respiratory tract, e.g. B. against Streptococcus pneumoniae .

pharmacology

Cethromycin inhibits bacterial protein synthesis by binding to the 50S subunit of the ribosomes . It interferes with the 23S rRNA of this subunit by binding to domains II and V. In addition, the formation of the 30S and 50S subunits is inhibited.

literature

• RR Reinert: Clinical efficacy of ketolides in the treatment of respiratory tract infections. In: The Journal of antimicrobial chemotherapy. Volume 53, Number 6, June 2004, pp. 918-927, doi : 10.1093 / jac / dkh169 , PMID 15117934 (review).
• JE Conte, JA Golden, J. Kipps, E. Zurlinden: Steady-state plasma and intrapulmonary pharmacokinetics and pharmacodynamics of cethromycin. In: Antimicrobial agents and chemotherapy. Volume 48, number 9, September 2004, pp. 3508-3515, doi : 10.1128 / AAC.48.9.3508-3515.2004 , PMID 15328118 , PMC 514776 (free full text).

Individual evidence

1. ^ The Merck Index. An Encyclopaedia of Chemicals, Drugs and Biologicals . 14th edition, 2006, p. 333, ISBN 978-0-911910-00-1 .
2. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !