Quinoline alkaloids

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Quinoline , the main body of the quinoline alkaloids

The quinoline alkaloids are naturally occurring chemical compounds from the group of alkaloids , which are chemically derived from quinoline . Some quinoline alkaloids show antiseptic , convulsive or antineoplastic effects.

Representative

Alkaloids with a quinoline partial structure are widespread and are usually further subdivided according to their occurrence and their biogenetic origin. The quinoline alkaloids include the china alkaloids (cinchona alkaloids) quinine and quinidine , which are important due to their therapeutic potential, cinchonine and cinchonidine , as well as some furoquinoline alkaloids and acridine alkaloids . Also strychnine and brucine , alkaloids of Brechnuss which have a hydrogenated quinoline system are counted as quinoline alkaloids. Also Nitra Marin (1- (2-quinolinyl) -β-carboline) is one of the quinoline alkaloids.

Occurrence

The quinoline alkaloids are mainly found in plants, such as in Rutaceae and Rubiaceae , but also in microorganisms and animals. In the redox factor PQQ ( pyrroloquinoline quinone ) and in the quinoenzymes , the quinoline is contained as a partial structure.

biosynthesis

Biogenetically , several pathways have been demonstrated for the development of the quinoline system in plants. Both tryptophan and anthranilic acid can act as precursors. The second precursor molecule is either a hemiterpene or a monoterpene ( e.g. secologanin in cinchona alkaloids).

literature