Chlorocruorin

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Chlorocruorin
Mass / length primary structure 165 amino acids , 18,492 Da
Identifier
External IDs

Structural formula of the chlorocruorin prosthetic group.

Chlorocruorin is the oxygen transporter of some marine annelids . It is in dissolved form in your blood and is responsible for its yellow-green color. In higher concentrations it is red as a dichromatic dye. As with hemoglobin , the oxygen is bound via divalent iron , which is associated with a porphyrin ring, but with a lower affinity . The molar mass is about 2750 to 3600  kDa , which makes it a comparatively very large protein, with repeating protein domains of about 17 kDa.

Its structure is similar to heme b . Instead of the formyl group, a vinyl group is located there at position 2 of the porphyrin ring. It is also similar to erythrocruorin . In contrast to hemoglobin in vertebrates, it is not present in blood cells, but freely in the Mixocoel .

Individual evidence

  1. ^ R. Wehner , W. Gehring | and Alfred Kühn: Zoology . Georg Thieme Verlag Stuttgart; 24th edition 2007; ISBN 978-3-13-367424-9 ; Page 339
  2. ^ H. Munro Fox: Chlorocruorin: A Pigment Allied to Haemoglobin . In: Proceedings of the Royal Society B . 99, No. 696, February 1, 1926, pp. 199-220. doi : 10.1098 / rspb.1926.0008 .
  3. ^ H. Munro Fox: The Oxygen Affinity of Chlorocruorin . In: Proceedings of the Royal Society B . 111, No. 772, September 1, 1932, pp. 356-363. doi : 10.1098 / rspb.1932.0060 .
  4. ^ H. Munro Fox: On Chlorocruorin and Hemoglobin . In: Proceedings of the Royal Society B . 136, No. 884, October 19, 1949, pp. 378-388. doi : 10.1098 / rspb.1949.0031 .
  5. ↑ Gerhard G. Habermehl, Peter E. Hammann, Hans C. Krebs and W. Ternes: Naturstoffchemie: An introduction . Springer Verlag Berlin; 3. completely revised u. exp. Edition 2008; ISBN 978-3-540-73732-2 ; P. 520
  6. ^ A b Pallavicini A, Negrisolo E, Barbato R: The primary structure of globin and linker chains from the chlorocruorin of the polychaete Sabella spallanzanii . In: J. Biol. Chem. . 276, No. 28, July 2001, pp. 26384-90. doi : 10.1074 / jbc.M006939200 . PMID 11294828 .
  7. ↑ Lamy JN, Green BN, Toulmond A, Wall JS, Weber RE, Vinogradov SN: Giant Hexagonal Bilayer Hemoglobins . In: Chem Rev . 96, No. 8, December 19, 1996, pp. 3113-3124. doi : 10.1021 / cr9600058 . PMID 11848854 .