Christoph Dehio

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Christoph Dehio, 2011

Christoph Dehio (born April 23, 1965 in Gelnhausen ) is a German infection biologist and professor at the Biozentrum of the University of Basel , Switzerland .

Life

Christoph Dehio studied biology at the University of Cologne and obtained his doctorate in 1992 at the Max Planck Institute for Plant Breeding Research in Cologne . As a postdoctoral fellow , he went to the Pasteur Institute in Paris for two years in 1993 . From 1995 to 2000 he was a research group leader at the Max Planck Institute for Biology in Tübingen . In 2000 Dehio came to the Biozentrum of the University of Basel as Professor of Molecular Microbiology , where he was made full professor in 2012 .

Act

Dehio is researching a virulence mechanism that is widespread in bacterial pathogens - so-called type 4 secretion systems inject bacterial effector proteins into host cells and thereby specifically change the cellular functions for the benefit of the pathogen. Using the pathogen Bartonella , he was able to demonstrate the gradual evolution of such secretion systems from the bacterial conjugation apparatus or the injected effector proteins from toxin-antitoxin modules. Using adaptive radiations , Dehio was also able to show that the acquisition of such secretion systems gives pathogens an increased adaptability to host organisms and thus contributes to the emergence of new pathogens with a changed host spectrum. His investigations into the function of the injected effector proteins show at the molecular level how they manipulate cellular functions in a targeted manner, in particular by suppressing inflammatory processes or programmed cell death , or by rearrangement of the cytoskeleton as the pathogen is absorbed into the cell interior.

Awards

Publications (selection)

Complete list of publications

  • P. Engel, A. Goepfert, FV Stanger, A. Harms, A. Schmidt, T. Schirmer, C. Dehio: Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. In: Nature 482, 2012, pp. 107-110, PMID 22266942 .
  • AT Pulliainen, K. Pieles, CS Brand, B. Hauert, A. Böhm, M. Quebatte, A. Wepf, M. Gstaiger, R. Aebersold, CW Dessauer, C. Dehio: Bacterial effector binds host cell adenylyl cyclase to potentiate Gαs-dependent cAMP production. In Proc Natl Acad Sci US A. 109, 2012, pp. 9581-9586, PMID 22635269 .
  • G. Schröder, R. Schülein, M. Quebatte, C. Dehio: Conjugative DNA-transfer into human cells by the VirB / VirD4 type IV scretion system of the bacterial pathogen Bartonella henselae. In: Proc. Natl. Acad. Sci. US A. 108, 2011, pp. 14643-14648, PMID 21844337 .
  • HL Saenz, P. Engel, MC Stoeckli, C. Lanz, G. Raddatz, M. Vayssier-Taussat, R. Birtles, SC Schuster, C. Dehio: Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors. In: Nat. Genet. 39, 2007, pp. 1469-1476, PMID 18037886 .
  • R. Schulein, P. Guye, TA Rhomberg, MC Schmid, G. Schroder, AC Vergunst, I. Carena, C. Dehio: A bipartite signal mediates the transfer of type IV secretion substrates of Bartonella henselae into human cells. In: Proc. Natl. Acad. Sci. US A. 102, 2005, pp. 856-861, PMID 15642951 .
  • R. Schülein, C. Dehio: The VirB / VirD4 type IV secretion system of Bartonella is essential for establishing intraerythrocytic infection. In: Mol. Microbiol. 46, 2002, pp. 1053-67, PMID 12421311 .
  • R. Schülein, A. Seubert, C. Gille, C. Lanz, Y. Hansmann, Y. Piémont, C. Dehio: Invasion and persistent intracellular colonization of erythrocytes. A unique parasitic strategy of the emerging pathogen Bartonella. In: J. Exp. Med. 193, 2001, pp. 1077-1086, PMID 11342592 .

Web links

Individual evidence

  1. ↑ Curriculum Vitae
  2. ↑ Nanomachines make microbes fit , scinexx.de, accessed on December 2, 2014.
  3. ↑ Christoph Dehio research group at the Biozentrum , accessed on December 2, 2014.
  4. ↑ resume keynote speaker , ncsu.edu, accessed December 2, 2014.
  5. ↑ People , zoominfo.com, accessed December 2, 2014.
  6. ↑ A Translocated Bacterial Protein Protects Vascular Endothelial Cells from Apoptosis , plospathogens.org, accessed December 2, 2014.
  7. ↑ Christoph Dehio receives Pfizer Research Prize 2006 , unibas.ch, accessed on December 2, 2014.
  8. ↑ Main prize of the German Society for Hygiene and Microbiology ( Memento of the original from March 4, 2016 in the Internet Archive ) Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice. , dghm.org, accessed December 2, 2014. @1@ 2Template: Webachiv / IABot / www.dghm.org
  9. ↑ Member entry of Christoph Dehio at the German Academy of Natural Scientists Leopoldina , accessed on April 5, 2015.
  10. ↑ EMBO Members 2013 , embo.org, accessed December 2, 2014.
  11. ↑ ERC Advanced Grants 2013 Results erc.europa.eu, accessed on December 2, 2014.
  12. ↑ Complete list of publications at Biozentrum.unibas.ch, accessed on December 2, 2014.
personal data
SURNAME Dehio, Christoph
BRIEF DESCRIPTION German infection biologist and professor at the Biozentrum of the University of Basel, Switzerland
DATE OF BIRTH April 23, 1965
PLACE OF BIRTH Gelnhausen