DNA replication licensing factor
| DNA replication licensing factor | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 821 amino acids | |
| Identifier | ||
| Gene name | MCM6 | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Eukaryotes | |
Mcm6 (in detail: DNA replication-licensing factor Mcm6 ) is a protein whose presence in the cell nucleus of eukaryotes is necessary to initiate DNA replication : After the G1 phase of cell division , Mcm6 binds to the chromatin ; this seems to be necessary to avoid multiple replication of the DNA.
In addition, Mcm6 is part of the MCM complex , which acts as a helicase and is responsible for untwisting the DNA before replication. One intron of the MCM6 - gene is in position as a promoter for the subsequent LCT gene ( lactase ); some variants of Mcm6 are therefore responsible for hereditary lactose intolerance , in particular for the large differences between European and non-European populations in this regard.
Proliferating Hodgkin's lymphoma cells and other cancer - cell lines have a high content of MCM6.
Web links
- reactome: Mcm2-7 associates with the Cdt1: CDC6: ORC: origin complex, forming the pre-replicative complex (preRC)
- reactome: Activation of the pre-replicative complex
- reactome: Unwinding of DNA
Individual evidence
- ↑ Orthologist at OMA
- ↑ UniProt Q14566
- ↑ reactome.org: Mcm4,6,7 trimer forms and associates with the replication fork ( page no longer available , search in web archives ) Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.
- ↑ Tye / reactome.org: MCM2-7 mediated fork unwinding ( page no longer available , search in web archives ) Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.
- ^ Tag CG, Oberkanins C, Kriegshäuser G, et al : Evaluation of a novel reverse-hybridization StripAssay for typing DNA variants useful in diagnosis of adult-type hypolactasia . In: Clin. Chim. Acta . 392, No. 1-2, June 2008, pp. 58-62. doi : 10.1016 / j.cca.2008.03.006 . PMID 18396155 .
- ↑ Karimi S. et al .: High Expression of Minichromosome Maintenance Protein 6 in Classic Hodgkin's Lymphoma Points to a Cell Cycle Arrest in G1 Phase. . In: Arch Iran Med. . 11, No. 5, 2008, pp. 532-538. PMID 18759521 .
- ↑ Xu J, Zhang S, You C, Huang S, Cai B, Wang X: Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor . In: J. Neurooncol. . 83, No. 2, June 2007, pp. 183-9. doi : 10.1007 / s11060-006-9284-0 . PMID 17410335 .
- ↑ Winnepenninckx V, Lazar V, Michiels S, et al : Gene expression profiling of primary cutaneous melanoma and clinical outcome . In: J. Natl. Cancer Inst. . 98, No. 7, April 2006, pp. 472-82. doi : 10.1093 / jnci / djj103 . PMID 16595783 .
