David Eisenberg
David Samuel Eisenberg (born March 15, 1939 in Chicago ) is an American biochemist.
Eisenberg studied at Harvard University (Bachelor 1961), where he studied with John T. Edsall and originally wanted to be a medical doctor, and received his doctorate in 1964 with Coulson at Oxford University (in theoretical chemistry). As a post-doctoral student he was at Princeton University from 1964 to 1966 with Walter Kauzmann and from 1966 to 1969 with Richard E. Dickerson at Caltech . Since 1969 he has been Professor of Biochemistry at the University of California, Los Angeles (UCLA), currently Paul D. Boyer Professor of Biochemistry and Molecular Biology . From 1993 he was the Director of The UCLA- DOE Institute of Genomics and Proteomics . He is also a member of the California NanoSystems Institute (CNSI) and has been with the Howard Hughes Medical Institute since 2000.
Eisenberg studied pathogenic protein interactions in neurodegenerative diseases, for example the amyloid fibrils in Alzheimer's disease and prions in Creutzfeldt-Jakob disease, for example . These diseases are characterized by incorrectly folded proteins that form the fibrils and which, in the case of prions, can also be infectious. For example, they were able to localize and crystallize the incorrectly folded parts in the Sup35 prion of wheat and use new methods of X-ray crystallography to clarify their three-dimensional structure, which revealed a close interlocking like in a zipper and explained the stability of the complexes.
Based on the protein interaction data obtained in the laboratory and collected in the Database of Interacting Proteins (DIP), his laboratory also examines networks of interacting proteins.
In addition, his laboratory is currently (2010) studying the structure of the tubercle bacillus .
In 1992 he succeeded in clarifying the three-dimensional structure of diphtheria toxin in his laboratory in collaboration with the laboratory of R. John Collier .
He was a Sloan Research Fellow from 1969 to 1971 and a Guggenheim Fellow in 1985. In 2008 he received the Harvey Prize . He became a member of the National Academy of Sciences in 1989 and has been a member of the American Academy of Arts and Sciences since 1991 . In 2001 he was elected a Fellow of the American Association for the Advancement of Science , and in 2003 he became a member of the American Philosophical Society . In 2004 he received the Seaborg Medal of UCLA, in 2020 the Passano Award .
He has been married since 1963 and has two children.
Web links
- Portrait at the Howard Hughes Medical Institute
- Website of his research group at the UCLA-DOE Institute
- Literature by and about David Eisenberg in the WorldCat bibliographic database
| personal data | |
|---|---|
| SURNAME | Eisenberg, David |
| ALTERNATIVE NAMES | Eisenberg, David Samuel |
| BRIEF DESCRIPTION | American biochemist |
| DATE OF BIRTH | March 15, 1939 |
| PLACE OF BIRTH | Chicago |