Dennis Liotta

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Dennis Liotta, 2018

Dennis C. Liotta (born January 31, 1949 in Brooklyn , New York ) is an American chemist and pharmacologist. Together with Raymond F. Schinazi and Woo-Baeg Cho, he discovered the active ingredient emtricitabine for the treatment of HIV infections and for AIDS prophylaxis. Liotta was also involved in the discovery of other active ingredients for the treatment of HIV and other infections.

Life

Liotta received her PhD in organic chemistry from the City University of New York in 1974 with Robert R. Engel and went to Ohio State University as a postdoctoral fellow . Her dissertation was entitled An investigation of some synthetically useful decarboxylation reactions . In 1980 he received a research grant from the Alfred P. Sloan Foundation ( Sloan Research Fellowship ). In 2002 he became a Fellow of the American Association for the Advancement of Science . He has been a member of the National Academy of Inventors since 2013.

research

Liotta and Schinazi began their AIDS-related work in the mid-1980s with the establishment of the first HIV laboratory at Emory University in Georgia .

Discovery of emtricitabine

Emtricitabine was discovered by Dennis C. Liotta with Raymond F. Schinazi and Woo-Baeg Choi and licensed to Triangle Pharma by Emory University in 1996. Triangle was acquired by Gilead in 2003 . Emtricitabine, marketed by Gilead as Emtriva, was first approved by the US Food and Drug Administration in July 2003 for the treatment of HIV infection in combination with other antiretroviral agents.

Liotta and Schinazi received the Georgia Biomedical Partnership's highest honor, the Biomedical Industry Growth Award , in 2003 for a number of significant contributions to research that led to successful drug development.

The Emory Office of Technology Transfer estimates that more than 90% of all HIV-infected people in the United States are taking, or have taken, any of the drugs he invented.

More discoveries

Liotta's research contributions aren't limited to AIDS:

He also discovered the drug lamivudine which was approved as the first treatment for hepatitis B.

He also founded Pharmasset (acquired by Gilead Sciences) which developed sofosbuvir , a pre-eminent drug for the treatment of hepatitis C.

In his current role as director of the Institute for Drug Development at Emory University, he was involved in the discovery and development of a nucleoside analog, EIDD-2023 , for the treatment of hepatitis C infections.

His research group also discovered the first dual tropical (CCR5 / CXCR4) HIV entry inhibitor.

Total Liotta is for the development of drugs Epivir , Combivir , Trizivir , Epzicom , Epivir-HBV , Emtriva , Truvada , Atripla , Complera and Stribid responsible.

Company formation

Liotta has founded numerous companies, including:

  • Altiris (Developing Stem Cell Mobilization Drugs as Potential Treatments for a Variety of Cancers)
  • Triangle Pharmaceuticals (Developed Emtricitabine and was subsequently acquired by Gilead Science)
  • NeurOp (Develops therapies for the treatment of ischemic diseases, such as stroke)
  • QUE Oncology (A joint venture owned by the Universities of Queensland and Emory that is conducting clinical trials with Q-122)
  • DRIVE (Drug Innovation Ventures at Emory, a non-profit pharmaceutical company researching therapies for the treatment of RNA viral infections)

Web links

Individual evidence

  1. ^ Biographical data, publications and academic family tree of Dennis C. Liotta at academictree.org, accessed on May 26, 2018.
  2. ^ The Emory University - Leadership Team Emory University
  3. ^ Past Fellows. Alfred P. Sloan Foundation, accessed July 10, 2019 .
  4. ↑ SCIENCES AND ROYALTY PHARMA ANNOUNCE $ 525 MILLION AGREEMENT WITH EMORY UNIVERSITY TO PURCHASE ROYALTY INTEREST FOR EMTRICITABINE Emory University July 2005
  5. ↑ a b c The Liotta Research Group: Dr. Dennis Liotta. Retrieved July 6, 2017 .
personal data
SURNAME Liotta, Dennis
ALTERNATIVE NAMES Liotta, Dennis C.
BRIEF DESCRIPTION American chemist and pharmacologist
DATE OF BIRTH January 31, 1949
PLACE OF BIRTH Brooklyn , New York