Deoxythymidine triphosphate

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Structural formula
Structure of deoxythymidine triphosphate
General
Surname Deoxythymidine triphosphate
other names
  • 2'-deoxthymidine-5'-triphosphate
  • [(2 R , 3 S , 5 R ) -3-hydroxy-5- (5-methyl-2,4-dioxopyrimidin-1-yl) oxolan-2-yl] methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate
Molecular formula C 10 H 17 N 2 O 14 P 3
External identifiers / databases
CAS number 365-08-2
EC number 206-669-7
ECHA InfoCard 100.006.064
PubChem 64968
ChemSpider 58493
DrugBank DB02452
Wikidata Q303961
properties
Molar mass 482.17 g mol −1
safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Deoxythymidine triphosphate (dTTP) is one of four building blocks of nucleic acid DNA . It consists of a deoxyribose , the base thymine and a triphosphate group.

biosynthesis

The deoxyribonucleoside triphosphates are synthesized in the cell as high-energy compounds from 2'-deoxyribonucleotide-5'-monophosphate through two successive phosphorylation steps with ATP as a phosphate group donor.

function

dTTP is a starting material in the synthesis of DNA. When it attaches to the DNA strand, pyrophosphate is split off. The genetic code of the DNA results from the base sequence of the DNA building blocks. Since the base of dTTP is thymine , this building block encodes the T of this code.

See also

literature

  • Jeremy M. Berg, John L. Tymoczko, Lubert Stryer : Biochemistry. 6 edition, Spektrum Akademischer Verlag, Heidelberg 2007, ISBN 978-3-8274-1800-5 .
  • Donald Voet, Judith G. Voet: Biochemistry. 3rd edition, John Wiley & Sons, New York 2004, ISBN 0-471-19350-X .
  • Bruce Alberts , Alexander Johnson, Peter Walter, Julian Lewis, Martin Raff, Keith Roberts: Molecular Biology of the Cell , 5th Edition, Taylor & Francis 2007, ISBN 978-0-81534106-2 .

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

literature

  • Peter Karlson: Short textbook of biochemistry . 12th edition, Thieme, Stuttgart, New York 1984, ISBN 3-13-357812-X .