Diloxanide furoate

Structural formula
General
Non-proprietary name	Diloxanide
other names	Diloxanide (furan-2-carboxylate); 4- (2,2-dichloro- N- methylacetamido) phenyl-2-furancarboxylate ( IUPAC );
Molecular formula	C 14 H 11 Cl 2 NO 4
External identifiers / databases
EC number	223-108-1
ECHA InfoCard	100.021.008
PubChem	19529
DrugBank	DB08792
Wikidata	Q799564
Drug information
ATC code	P01 AC01
properties
Molar mass	328.22 g · mol -1
Physical state	firmly
Melting point	114-116 ° C
solubility	very sparingly soluble in water ; heavy in ethanol ; good in chloroform ;
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Diloxanide furoate is a medicine used to treat amoebic dysentery , a diarrheal disease caused by a specific microorganism. The substance acts as a contact amebicide in the intestinal lumen and is the agent of choice for symptom-free infections of the intestinal lumen and for follow-up treatment following therapy for invasive infections caused by amoeba.

Diloxanide furoate has been on the World Health Organization's list of Essential Medicines since 1988 . The drug was discovered by The Boots Company Plc in 1956 and marketed as a drug under the name Furamid . Abbott Laboratories now owns the trademark rights.

Diloxanide furoate is an ester of furan-2-carboxylic acid with diloxanide.

Individual evidence

↑ ^a ^b ^c ^d Pharmaceutical Substance List, 12th Edition 2001, Advertising and Sales Association of German Pharmacists.
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ Fernandes H, D'Souza CR, Swethadri GK, Naik CN: Ameboma of the colon with amebic liver abscess mimicking metastatic colon cancer . In: Indian J Pathol Microbiol . 52, No. 2, 2009, pp. 228-230. doi : 10.4103 / 0377-4929.48927 . PMID 19332922 .
↑ G.-D. Burchard et al .: Amoebic dysentery and amoebic liver abscess , Dtsch Arztebl 1996; 93 (51-52): A-3410 / B-2874 / C-2670.
↑ Christina Hohmann: Gut in Aufruhr , Pharmazeutische Zeitung, issue 34/2002.

[psl-1] Pharmaceutical Substance List, 12th Edition 2001, Advertising and Sales Association of German Pharmacists.

[NV-2] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[3] Fernandes H, D'Souza CR, Swethadri GK, Naik CN: Ameboma of the colon with amebic liver abscess mimicking metastatic colon cancer . In: Indian J Pathol Microbiol . 52, No. 2, 2009, pp. 228-230. doi : 10.4103 / 0377-4929.48927 . PMID 19332922 .

[4] G.-D. Burchard et al .: Amoebic dysentery and amoebic liver abscess , Dtsch Arztebl 1996; 93 (51-52): A-3410 / B-2874 / C-2670.

[5] Christina Hohmann: Gut in Aufruhr , Pharmazeutische Zeitung, issue 34/2002.