Dithioerythritol

Structural formula
General
Surname	Dithioerythritol
other names	1,4-dithioerythritol; Dithioerythritol; DTE; erythro -1,4-dimercapto-2,3-butanediol; (2 R , 3 S ) -1,4-bis (sulfanyl) butane-2,3-diol; (2 R , 3 S ) - 1,4-bis (sulfanyl) butane-2,3-diol; Cleland's reagent (also used for DTT);
Molecular formula	C 4 H 10 O 2 S 2
Brief description	white solid with an unpleasant odor
External identifiers / databases
EC number	229-998-8
ECHA InfoCard	100.027.271
PubChem	439352
DrugBank	DB01692
Wikidata	Q412701
properties
Molar mass	154.25 g mol −1
Physical state	firmly
Melting point	40–43 ° C ( DL - threo form); 50–52 ° C ( L - threo shape); 82–83 ° C ( erythro form);
solubility	good in water (1500 g l −1 , 20 ° C, DL - threo form)
safety instructions
GHS labeling of hazardous substances Caution
H and P phrases	H: 302-315-319-335
	P: 261-305 + 351 + 338
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

1,4-Dithioerythritol or dithioerythritol (DTE) is a chemical compound that is derived from the sugar alcohol erythritol by replacing the oxygen atoms in the terminal hydroxyl groups with sulfur atoms. Dithioerythritol is the diastereomer of dithiothreitol (DTT) and, like erythritol, is stereochemically a meso compound . DTE is a good reducing agent and, like DTT, cleaves disulfide bridges in proteins , which is why it is used in the sample buffer in SDS-PAGE, among other things .

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g Entry on 1,4-Dimercapto-2,3-butanediol in the GESTIS substance database of the IFA , accessed on January 10, 2017(JavaScript required) .