Donald S. Fredrickson

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Donald S. Fredrickson, 1961

Donald Sharp Fredrickson (born August 8, 1924 in Cañon City , † June 7, 2002 in Bethesda , Maryland ) was a physiologist and was the first to describe Tangier's disease in 1961 . Between 1975 and 1981, he held the office of director of the National Institutes of Health (NIH) , among numerous other outstanding positions. In 1973 he was elected to the National Academy of Sciences , 1975 to the American Academy of Arts and Sciences , and in 1978 he received a Gairdner Foundation International Award . Since 1985 he was a member of the American Philosophical Society . The classification of primary hyperlipoproteinemia is named after him.

Essential publications

His main publications were in the field of human fat metabolism and hereditary diseases .

  • Hoffman, Harry N., and Donald S. Fredrickson. Tangier Disease (Familial High Density Lipoprotein Deficiency): Clinical and Genetic Features in Two Adults. The American Journal of Medicine 39, 4 (October 1965): 582-593.
  • Fredrickson, Donald S., Robert I. Levy, and Robert S. Lees. Fat Transport in Lipoproteins - An Integrated Approach to Mechanisms and Disorders. New England Journal of Medicine, (1967): 1-46.
  • Personal reminiscence of President Lyndon B. Johnson's 1967 visit to NIH.
  • Pruitt, John. Tangier Disease: Tonsils May Cure Hearts. Virginian Pilot, (1967).
  • Fleischmajer, Raul, and Alan M. Schragger. Familial hyperlipoproteinemia. Hahnemann University, After 1969. Report.
  • Fredrickson, Donald S. et al. Report of the National Heart and Lung Institute Panel on Hyperlipidemia and Premature Atherosclerosis.
  • Clifton-Bligh, P., PJ Nestel, and HM Whyte. Tangier Disease: Report of a Case and Studies of Lipid Metabolism. New England Journal of Medicine 286, 11 (March 16, 1972): 567-571.
  • Tonsils and Apolipoproteins: Lessons about Plasma Lipoproteins Derived from Tangier Disease and Other Mutants. Jimenez Diaz Memorial Lectures, 1969-1974. Foundation Conchita Rabago, 1974. pp. 129-156.
  • Phenotyping: On Reaching Base Camp (1950-1975). Circulation (Supplement) 87, 4 (April 1993): III-1-III-15.
  • The First Heart Transplant in Man. Diary. Excerpt. Memoir. April 26, 1997.

Individual evidence

  1. ^ Profiles in Science: The Donald S. Fredrickson Papers - Biographical Information , online here
  2. ^ Hoffman, Harry N., and Donald S. Fredrickson: Tangier Disease (Familial High Density Lipoprotein Deficiency): Clinical and Genetic Features in Two Adults. In: The American Journal of Medicine 39, 4 (October 1965): 582-593; pdf
  3. ^ Profiles in Science: The Donald S. Fredrickson Papers - NIH Director, 1975-1981: Biomedical Research in a Time of Trial , online here
  4. ^ Member History: Donald S. Fredrickson. American Philosophical Society, accessed August 11, 2018 .
  5. ^ Profiles in Science: The Donald S. Fredrickson Papers - Lipid Metabolism and Genetic Disease, 1953-1974: Documents , online here
personal data
SURNAME Fredrickson, Donald S.
ALTERNATIVE NAMES Fredrickson, Donald Sharp
BRIEF DESCRIPTION American physiologist, first to describe Tangier disease
DATE OF BIRTH August 8, 1924
PLACE OF BIRTH Canyon City , Colorado
DATE OF DEATH June 7, 2002
Place of death Bethesda , Maryland