Douglas C. Rees

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Douglas Charles Rees (* 1952 ) is an American biochemist , biophysicist and structural biologist .

Rees graduated from Yale University with a bachelor's degree in 1974 and received a PhD in biophysics from Harvard University in 1980 . In 1982 he went to the University of California, Los Angeles . In 1989 he became Professor of Chemistry at Caltech . He is Roscoe Gilkey Dickinson Professor and Dean of the Graduate School there. From 1997 he was at the Howard Hughes Medical Institute .

He investigates the structure and function of metal-containing proteins, in particular nitrogenase in biological nitrogen fixation , and membrane proteins that bring about ATP- dependent transport through membranes (e.g. ABC transporters , which, for example, transport nutrients into bacterial cells and waste materials from the cell). To do this, he uses X-ray crystallography, which he came to in the 1970s as a student of Stephen C. Harrison and Don C. Wiley at Harvard, at a time when the role of X-ray crystallography was considered to be in decline. His interest in nitrogenase began in William Lipscomb's laboratory .

In 2015 he received the FA Cotton Medal , for 2020 he was awarded the Gregori Aminoff Prize . He is a member of the American Academy of Arts and Sciences and the National Academy of Sciences and was a Sloan Research Fellow .

Fonts (selection)

  • Editor with Daniel E. Atkinson, Steven G. Clarke, David S. Barkley: Dynamic models in biochemistry: a workbook of computer simulations using electronic spreadsheets , Benjamin Cummings 1987
  • as editor: Membrane proteins , Amsterdam / Boston: Academic Press, 2003, ISBN 978-0-080-49376-3
  • with JB Howard: Nitrogenase: a nucleotide-dependent molecular switch , Annual Review of Biochemistry, Volume 63, 1994, pp. 235-264.
  • with MH Stowell: Structure and stability of membrane proteins , Advances in Protein Chemistry, Volume 46, 1995, pp. 279-311
  • with JB Howard: Structural Basis of Biological Nitrogen Fixation , Chemical Reviews, Volume 96, 1996, pp. 2965-2982
  • with George Feher a . a .: Light-induced structural changes in photosynthetic reaction center: implications for mechanism of electron-proton transfer , Science, Volume 276, 1997, pp. 812-816
  • Great metalloclusters in enzymology , Annual Review of Biochemistry, Volume 71, 2002, pp. 221-246.
  • with JB Howard: Nitrogenase: standing at the crossroads , Current Opinion in Chemical Biology, Volume 4, 2002, pp. 559-566
  • with F. Akif Tezcan, Chad A. Haynes, Mika Y. Walton, Susana Andrade, Oliver Einsle, James B. Howard: Structural basis of biological nitrogen fixation , Phil. Trans. R. Soc. A, Volume 363, 2005, pp. 971-984
  • with FA Tezcan, JT Kaiser, D. Mustafi, MY Walton, JB Howard: Nitrogenase Complexes: Multiple Docking Sites for a Nucleotide Switch Protein , Science, Volume 309, 2005, pp 1377-1380
  • with Chris Gandhi: Opening the molecular floodgates , Science, Volume 321, 2008, pp. 1166–1167
  • with NS Kadaba u. a .: The high-affinity E. coli methionine ABC transporter: structure and allosteric regulation , Science, Volume 321, 2008, pp. 250-253
  • with E. Johnson, O. Lewinson: ABC Transporters: The Power to Change , Nature Reviews Molecular Cell Biology, Volume 10, 2009, pp. 218-227
  • with JB Howard u. a .: Ligand binding to the FeMo-cofactor: structures of CO-bound and reactivated nitrogenase , Science, Volume 345, 2014, pp. 1620-1623

Web links

Individual evidence

  1. ↑ Career data according to Pamela Kalte u. a., American Men and Women of Science, Thomson Gale 2004
personal data
SURNAME Rees, Douglas C.
ALTERNATIVE NAMES Rees, Douglas Charles
BRIEF DESCRIPTION American biochemist, biophysicist, and structural biologist
DATE OF BIRTH 1952