Douglas C. Rees
Douglas Charles Rees (* 1952 ) is an American biochemist , biophysicist and structural biologist .
Rees graduated from Yale University with a bachelor's degree in 1974 and received a PhD in biophysics from Harvard University in 1980 . In 1982 he went to the University of California, Los Angeles . In 1989 he became Professor of Chemistry at Caltech . He is Roscoe Gilkey Dickinson Professor and Dean of the Graduate School there. From 1997 he was at the Howard Hughes Medical Institute .
He investigates the structure and function of metal-containing proteins, in particular nitrogenase in biological nitrogen fixation , and membrane proteins that bring about ATP- dependent transport through membranes (e.g. ABC transporters , which, for example, transport nutrients into bacterial cells and waste materials from the cell). To do this, he uses X-ray crystallography, which he came to in the 1970s as a student of Stephen C. Harrison and Don C. Wiley at Harvard, at a time when the role of X-ray crystallography was considered to be in decline. His interest in nitrogenase began in William Lipscomb's laboratory .
In 2015 he received the FA Cotton Medal , for 2020 he was awarded the Gregori Aminoff Prize . He is a member of the American Academy of Arts and Sciences and the National Academy of Sciences and was a Sloan Research Fellow .
Fonts (selection)
- Editor with Daniel E. Atkinson, Steven G. Clarke, David S. Barkley: Dynamic models in biochemistry: a workbook of computer simulations using electronic spreadsheets , Benjamin Cummings 1987
- as editor: Membrane proteins , Amsterdam / Boston: Academic Press, 2003, ISBN 978-0-080-49376-3
- with JB Howard: Nitrogenase: a nucleotide-dependent molecular switch , Annual Review of Biochemistry, Volume 63, 1994, pp. 235-264.
- with MH Stowell: Structure and stability of membrane proteins , Advances in Protein Chemistry, Volume 46, 1995, pp. 279-311
- with JB Howard: Structural Basis of Biological Nitrogen Fixation , Chemical Reviews, Volume 96, 1996, pp. 2965-2982
- with George Feher a . a .: Light-induced structural changes in photosynthetic reaction center: implications for mechanism of electron-proton transfer , Science, Volume 276, 1997, pp. 812-816
- Great metalloclusters in enzymology , Annual Review of Biochemistry, Volume 71, 2002, pp. 221-246.
- with JB Howard: Nitrogenase: standing at the crossroads , Current Opinion in Chemical Biology, Volume 4, 2002, pp. 559-566
- with F. Akif Tezcan, Chad A. Haynes, Mika Y. Walton, Susana Andrade, Oliver Einsle, James B. Howard: Structural basis of biological nitrogen fixation , Phil. Trans. R. Soc. A, Volume 363, 2005, pp. 971-984
- with FA Tezcan, JT Kaiser, D. Mustafi, MY Walton, JB Howard: Nitrogenase Complexes: Multiple Docking Sites for a Nucleotide Switch Protein , Science, Volume 309, 2005, pp 1377-1380
- with Chris Gandhi: Opening the molecular floodgates , Science, Volume 321, 2008, pp. 1166–1167
- with NS Kadaba u. a .: The high-affinity E. coli methionine ABC transporter: structure and allosteric regulation , Science, Volume 321, 2008, pp. 250-253
- with E. Johnson, O. Lewinson: ABC Transporters: The Power to Change , Nature Reviews Molecular Cell Biology, Volume 10, 2009, pp. 218-227
- with JB Howard u. a .: Ligand binding to the FeMo-cofactor: structures of CO-bound and reactivated nitrogenase , Science, Volume 345, 2014, pp. 1620-1623
Web links
- Rees Lab
- Website on the HHMI
- Literature by and about Douglas C. Rees in the WorldCat bibliographic database
Individual evidence
personal data | |
---|---|
SURNAME | Rees, Douglas C. |
ALTERNATIVE NAMES | Rees, Douglas Charles |
BRIEF DESCRIPTION | American biochemist, biophysicist, and structural biologist |
DATE OF BIRTH | 1952 |