Ethan M. Shevach

Ethan M. Shevach (* 1943 ) is an immunologist at the National Institute of Allergy and Infectious Diseases (NIAID) in Bethesda , Maryland .

Live and act

Shevach acquired in 1967 at the Boston University to MD as graduation from medical school. After a few years of clinical training, he took on a position as a research assistant (senior staff fellow) at NIAID in 1972 , in 1973 he became head of a research group (senior investigator) and in 1987 he was head of department (section chief) . Today (as of 2015) he is head of the department for cellular immunology at NIAID.

From 1987 to 1992 he was a senior editor of the scientific journal Journal of Immunology (Published by the American Association of Immunologists ) and from 1996 to 2007, the journal Cellular Immunology .

Shevach was able to contribute significantly to the elucidation of the function of the regulatory T-cell and the transcription factor FOXP3 .

In 2004 the Cancer Research Institute awarded him the William B. Coley Award for Distinguished Research in Basic and Tumor Immunology . Since 2015 Thomson Reuters Shevach has been one of the favorites for a Nobel Prize in Physiology or Medicine due to the large number of his citations .

Publications (selection)

• YC Kim, R. Bhairavabhotla, J. Yoon, A. Golding, AM Thornton, DQ Tran, EM Shevach: Oligodeoxynucleotides stabilize Helios-expressing Foxp3 + human T regulatory cells during in vitro expansion. In: Blood. Volume 119, number 12, March 2012, pp. 2810-2818, doi: 10.1182 / blood-2011-09-377895 , PMID 22294730 , PMC 3327459 (free full text).
• EM Shevach: Biological functions of regulatory T cells. In: Advances in immunology. Volume 112, 2011, pp. 137-176, doi: 10.1016 / B978-0-12-387827-4.00004-8 , PMID 22118408 (review).
• TS Davidson, EM Shevach: Polyclonal Treg cells modulate T effector cell trafficking. In: European Journal of Immunology. Volume 41, number 10, October 2011, pp. 2862-2870, doi: 10.1002 / eji.201141503 , PMID 21728170 , PMC 3813905 (free full text).
• Q. Chen, YC Kim, A. Laurence, GA Punkosdy, EM Shevach: IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3 + T cells in vivo. In: Journal of Immunology (Baltimore, Md.: 1950). Volume 186, number 11, June 2011, pp. 6329-6337, doi: 10.4049 / jimmunol.1100061 , PMID 21525380 , PMC 3098943 (free full text).
• EM Shevach: The resurrection of T cell-mediated suppression. In: Journal of Immunology (Baltimore, Md.: 1950). Volume 186, Number 7, April 2011, pp. 3805-3807, doi: 10.4049 / jimmunol.1100364 , PMID 21422250 .
• GA Punkosdy, M. Blain, DD Glass, MM Lozano, L. O'Mara, JP Dudley, R. Ahmed, EM Shevach: Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens. In: Proceedings of the National Academy of Sciences . Volume 108, number 9, March 2011, pp. 3677-3682, doi: 10.1073 / pnas.1100213108 , PMID 21321220 , PMC 3048095 (free full text).

Web links

• Ethan M. Shevach, MD at the National Institute of Allergy and Infectious Diseases (niaid.nih.gov)

Individual evidence

1. ^ William B. Coley Award. In: cancerresearch.org. Retrieved September 25, 2015 . 
2. ↑ The 2015 Thomson Reuters Citation Laureates. In: stateofinnovation.thomsonreuters.com. Retrieved September 25, 2015 .