Eupyrin
| Structural formula | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
||||||||||
| General | ||||||||||
| Surname | Eupyrin | |||||||||
| other names |
|
|||||||||
| Molecular formula | C 19 H 21 NO 5 | |||||||||
| Brief description |
Pale greenish-yellow needles, smell of vanillin |
|||||||||
| External identifiers / databases | ||||||||||
|
||||||||||
| properties | ||||||||||
| Molar mass | 343.38 g mol −1 | |||||||||
| Physical state |
firmly |
|||||||||
| Melting point |
87-88 ° C |
|||||||||
| solubility |
|
|||||||||
| safety instructions | ||||||||||
|
||||||||||
| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | ||||||||||
As Eupyrin formerly the Vanillinethylcarbonat- was p -phenetidin (alternate spelling: Vanillinäthylkarbonatparaphenetidin ), respectively. It was used as a remedy for fever.
properties
Eupyrin belongs to the phenetidine group . They are greenish-yellow needles and are tasteless. Eupyrin is sparingly soluble in water, but easily soluble in alcohol . It melts at 87 ° C to 88 ° C and smells very faintly of vanillin. It has an antipyretic and stimulating effect at the same time, which is why it was used at the beginning of the 20th century as a mild and non-toxic febrile medicine in children, old people and in febrile cases with considerable weakness, where other febrile drugs were excluded because of the risk of collapse.
marketing
Eupyrin was marketed by the United Quinine Factory Zimmer & Co in Frankfurt at the beginning of the 20th century as a finished medicinal product (powder) and given several times a day by the gram.
The flu tablets called Eupyrin from Boehringer Mannheim in the early 1950s, which contained salicylamide and quinine , had a different composition . In Pakistan, a company produces painkillers with codeine and paracetamol under the trade name Eupyrin .
literature
- Eupyrin . In: C. Bachem: Newer Medicines. Their composition, effect and application . CJ Göschen'sche Verlagsbuchhandlung, Berlin / Leipzig 1918, p. 60. ( digitized at the TU Braunschweig)
Web links
- The historical finished drug Eupyrin from the United Chininfabriken Zimmer & Co (Frankfurt am Main) on the website of the South Tyrolean Citizens' Network
Individual evidence
- ↑ a b c d G. Frerichs, G. Arends, H. Zörnig (Ed.): Hager's Handbook of Pharmaceutical Practice for Pharmacists, Pharmaceutical Manufacturers, Druggists, Doctors and Medical Officials , Volume Two, Springer Verlag, 1949, p. 411.
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ a b Eupyrīn . In: Meyers Großes Konversations-Lexikon . 6th edition. Volume 6, Bibliographisches Institut, Leipzig / Vienna 1906, p. 169 .
- ↑ G. Arends, A. Rathje: New medicines and pharmaceutical specialties. 4th edition, Springer-Verlag Berlin / Heidelberg 1913; Pp. 193-194.
- ↑ C. Bachem: Newer Medicines. Their composition, effect and application , p. 60.
- ↑ Pharmaceutical packaging through the ages, July 1, 2017 at www.meditipps.de. Retrieved April 3, 2019.
- ↑ Postcard advertisement for Eupyrin from 1951 , accessed April 3, 2019.
- ↑ Eupyrin on the Unexo Labs (Pvt) Ltd. website , accessed on April 3, 2019.