Flubromazolam
| Structural formula | ||||||||||
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| General | ||||||||||
| Surname | Flubromazolam | |||||||||
| other names |
8-Bromo-6- (2-fluorophenyl) -1-methyl-4 H - [1,2,4] triazolo [4,3- a ] [1,4] benzodiazepine |
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| Molecular formula | C 17 H 12 BrFN 4 | |||||||||
| Brief description |
white solid |
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| properties | ||||||||||
| Molar mass | 371.21 g mol −1 | |||||||||
| Physical state |
firmly |
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| Melting point |
205 ° C |
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| solubility |
soluble in ethanol, DMSO and DMF |
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| safety instructions | ||||||||||
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | ||||||||||
Flubromazolam is a chemical compound of bromine from the group of triazolobenzodiazepines . The compound was never marketed as a drug, but is emerging as a designer drug . The compound is highly effective and can cause anesthesia and amnesia even with an oral dose of 0.5 mg.
Extraction and presentation
Flubromazolam can be prepared by reacting 1-acetyl-1,2,4-triazole with flubromazepam .
properties
Flubromazolam has a long half-life of around 20 hours, compared to the parent compound flubromazepam (half-life: 106 hours), flubromazolam has a shorter half-life and a significantly increased potency, 200 µg flubromazolam corresponds to 4 mg flubromazepam. A monohydroxylated and a debrominated compound could be identified as metabolites , the former being detected in the analysis of urine samples for up to 28 days after ingestion. Flubromazolam can be detected by various methods, such as nuclear magnetic resonance spectroscopy / gas chromatography - mass spectrometry NMR / GC-MS, liquid chromatography -mass spectrometry (LC-MS / MS) or liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-ToF-MS), respectively.
Individual evidence
- ↑ a b flubromazolam. (PDF) In: swgdrug.org. Retrieved August 30, 2017 .
- ↑ Flubromazolam. In: Cayman Chemical. Retrieved August 30, 2017 .
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ M. Łukasik-Głębocka, K. Sommerfeld, A. Teżyk, B. Zielińska-Psuja, P. Panieński, C. Żaba: Flubromazolam - A new life-threatening designer benzodiazepine. In: Clin Toxicol. 54, 2016, pp. 66-68, PMID 26585557 .
- ↑ Bjoern Moosmann, Leslie A. King, Volker Auwärter: Designer benzodiazepines: A new challenge. In: World Psychiatry. 14, 2015, p. 248, doi : 10.1002 / wps.20236 .
- ↑ Flubromazolam Scientific Information. In: Flubromazolam.com. Retrieved August 30, 2017 .
- ↑ B. Moosmann, LM Huppertz, M. Hutter, A. Buchwald, S. Ferlaino, V. Auwärter: Detection and identification of the designer benzodiazepine flubromazepam and preliminary data on its metabolism and pharmacokinetics. In: J Mass Spectrom. 48, 2013, pp. 1150-1159, PMID 24259203 .
