GGPP synthase
GGPP synthase | ||
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Ribbon model of the hexamer with GGPP as calottes according to PDB 2Q80 | ||
Properties of human protein | ||
Mass / length primary structure | 300 amino acids | |
Secondary to quaternary structure | Homohexamer (3 * dimer) | |
Cofactor | 3 Mg 2+ | |
Identifier | ||
Gene name | GGPS1 | |
External IDs | ||
Enzyme Classifications | ||
EC, category | 2.5.1.1 , transferase | |
Response type | Transfer of a prenyl residue | |
Substrate | DMAPP + IPP | |
Products | Geranyl diphosphate + PP i | |
EC, category | 2.5.1.10 , transferase | |
Response type | Transfer of a geranyl residue | |
Substrate | Geranyl diphosphate + IPP | |
Products | Farnesyl diphosphate + PP i | |
EC, category | 2.5.1.29 , transferase | |
Response type | Transfer of a farnesyl residue | |
Substrate | Farnesyl diphosphate + IPP | |
Products | GGPP + PP i | |
Occurrence | ||
Parent taxon | Creature |
GGPP synthetase (GGPPSase) is the enzyme in animals , comprising the condensation reaction of several isopentenyl diphosphate (IPP) molecules together with dimethylallyl diphosphate (DMAPP) to farnesyl diphosphate catalyzed , two steps in the biosynthesis of cholesterol . Another step to geranylgeranyl diphosphate (GGPP) is possible; GGPP participates in the post-translational modification of proteins and plays a role in cell apoptosis . In humans, GGPPSase is found in all tissue types, but is expressed in particularly large amounts in the testes .
Catalyzed reactions
Isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) condense to geranyl diphosphate.
Isopentenyl diphosphate (IPP) and geranyl diphosphate condense to form farnesyl diphosphate.
Individual evidence
Web links
- Jassal / reactome: Addition of isopentenyl pyrophosphate to DMAPP
- Jassal / reactome: Another isopentenyl pyrophosphate is added to geranyl pyrophosphate