GMP reductase
| GMP reductase | ||
|---|---|---|
|
||
| Mass / length primary structure | 345/348 amino acids | |
| Secondary to quaternary structure | Homotetramer | |
| Isoforms | 4th | |
| Identifier | ||
| Gene name (s) | GMPR , GMPR2 | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 1.7.1.7 , oxidoreductase | |
| Response type | red. Deamination | |
| Substrate | GMP + NADPH / H + | |
| Products | IMP + NH 3 + NADP + | |
| Occurrence | ||
| Parent taxon | Eukaryotes , bacteria | |
GMP reductases (GMPR) are enzymes in eukaryotes and bacteria that catalyze the deamination of GMP to IMP . These reactions serve to restore and maintain the balance of purine nucleotides in the cell.
Humans have two genes that code for GMPR ( GMPR and GMPR2 on chromosomes 6 and 114), each of which creates two splice variants . GMPR2 may have another role in the differentiation of monocytes .
Catalyzed reaction
+ NADPH / H + + NH 3 + NADP +
Ammonia is split off from GMP and IMP is created. The reaction is irreversible.
Individual evidence
- ↑ UniProt P36959 , UniProt Q9P2T1
- ↑ GMPR and GMPR2
- ↑ J. Zhang, W. Zhang, D. Zou, G. Chen, T. Wan, M. Zhang, X. Cao: Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL -60 leukemia cells. In: Journal of Cancer Research and Clinical Oncology . Volume 129, Number 2, February 2003, pp. 76-83, ISSN 0171-5216 . doi : 10.1007 / s00432-002-0413-7 . PMID 12669231 .
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Purine Metabolism - Learning and Teaching Materials
