|Molecular formula||C 10 H 14 N 5 O 8 P|
|External identifiers / databases|
|Molar mass||363.22 g mol −1|
190–200 ° C (decomposition)
|As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .|
Guanosine monophosphate (GMP) is a nucleotide , the phosphoric acid ester of the nucleoside guanosine . Together with adenosine monophosphate ( AMP ), cytidine monophosphate ( CMP ) and uridine monophosphate ( UMP ), it forms the basic building blocks of ribonucleic acid ( RNA ).
Natural occurrence, importance, extraction
As a component of RNA, GMP occurs in all living things. The RNA is used in cells to convert genetic information from deoxyribonucleic acid ( DNA ) into proteins . It is usually produced industrially with the help of microorganisms, which can also be genetically modified .
Guanosine monophosphate is approved in the EU as a food additive with the number E 626 up to a maximum amount of 500 mg / kg for all foodstuffs approved for additives. Like the disodium (E 627), dipotassium (E 628) and calcium salts (E 629), it is used as a flavor enhancer , the compounds being about 10 to 20 times more effective than glutamic acid ( glutamate ). With the addition of small amounts, the taste of many foods (especially ready-made products and canned meals) is enhanced and some undesirable taste nuances are eliminated. In connection with glutamate, GMP and its salts work synergistically and increase the taste-enhancing effect even in low proportions, around 1:10.
Table of E numbers
|E number||Surname||Molecular formula||CAS|
|E 626||Guanosine monophosphate||C 10 H 14 N 5 O 8 P||85-32-5|
|E 627||Disodium guanylate||C 10 H 12 N 5 O 8 PNa 2||13474-02-7|
|E 628||Dipotassium guanylate||C 10 H 12 N 5 O 8 PK 2||3254-39-5|
|E 629||Calcium guanylate||C 10 H 12 N 5 O 8 PCa||38966-30-2|
- Guanosine monophosphate . Food lexicon
- Entry on E 626: Guanylic acid in the European database on food additives, accessed on August 11, 2020.
- Entry on guanosine 5′-monophosphate. In: Römpp Online . Georg Thieme Verlag, accessed on December 28, 2014.
- This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- Annals of the New York Academy of Sciences . Vol. 60, Pg. 251, 1954.
- Entry on guanosine monophosphate in the ChemIDplus database of the United States National Library of Medicine (NLM) .
- Wissenschaft-Online-Lexika: Entry on guanylic acid (E 626) in the Lexicon of Nutrition , accessed on January 7, 2009.
- E. Lück, H. Gölitz, P. Kuhnert: Lexicon of food additives. Behr's Verlag DE, 1998, ISBN 978-3-86022-462-5 , p. 97.