Galactose-1-phosphate uridyl transferase
| Galactose-1-phosphate uridyl transferase | ||
|---|---|---|
|
||
| Band model of the GALT according to PDB 1GUP | ||
| Properties of human protein | ||
| Mass / length primary structure | 379 amino acids | |
| Secondary to quaternary structure | Homodimer | |
| Cofactor | Zinc, iron | |
| Identifier | ||
| Gene name | GALT | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 2.7.7.12 , nucleotidyl transferase | |
| Response type | Transmission of UDP | |
| Substrate | UDP-glucose + α- D- galactose-1-phosphate | |
| Products | UDP-galactose + α- D -glucose-1-phosphate | |
| Occurrence | ||
| Homology family | GALT | |
| Parent taxon | Eukaryotes , some bacteria | |
Galactose-1-phosphate uridyl transferase (GALT) is an enzyme . It binds the galactose in galactose-1-phosphate to UDP ; this is the second step in the breakdown of galactose. GALT occurs in eukaryotes and a few bacteria . Mutations in the GALT - gene in humans can and GALT deficiency this to classical galactosemia lead.
Catalyzed equilibrium
+ +
UDP is transferred from UDP-glucose to galactose and vice versa.
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Galactose Metabolism - Learning and Teaching Materials
