Gallopamil

Structural formula
	1: 1 mixture of ( R ) -form (top) and ( S ) -form (bottom)
General
Non-proprietary name	Gallopamil
other names	( RS ) -5 - [(3,4-Dimethoxyphenethyl) methyl-amino] -2-isopropyl-2- (3,4,5-trimethoxyphenyl) pentanenitrile ( IUPAC ) ; (±) -Methoxyverapamil;
Molecular formula	C 28 H 40 N 2 O 5 (gallopamil); C 28 H 40 N 2 O 5 · HCl ( hydrochloride );
Brief description	yellow viscous oil (gallopamil)
External identifiers / databases
PubChem	1234
ChemSpider	1197
DrugBank	DB12923
Wikidata	Q412127
Drug information
ATC code	C08 DA02
Drug class	Calcium antagonist
properties
Molar mass	484.63 g mol −1 (gallopamil); 521.10 g mol −1 (hydrochloride);
Melting point	145–148 ° C (hydrochloride, racemate ); 160.5–161.5 ° C ( L- gallopamil hydrochloride); 160.5–161.5 ° C ( D- gallopamil hydrochloride);
boiling point	240–245 ° C (0–26.6 Pa, gallopamil)
Refractive index	1.5402 (hydrochloride)
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances Hydrochloride;	no GHS pictograms
	no GHS pictograms
H and P phrases	H: no H-phrases
	P: no P-phrases
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

Gallopamil is a drug from the nitrile group . It exists as a racemate .

properties

It is a calcium antagonist and calcium channel blocker . This property has the consequence that the Ca ²⁺ ions cannot diffuse into the cells as in the undisturbed state . A muscle contraction remains of why or relaxes, causing the blood vessels wide or the heart muscle itself is relaxed.

Gallopamil is used in medicine for the treatment of cardiovascular diseases , especially for diseases of the coronary arteries , e.g. B. angina pectoris , cardiac arrhythmias or high blood pressure are used.

Monopreparate
Procorum (D; former trade name, wastaken off the marketin April 2012 by the manufacturer Abbot in Germany)

Entry on gallopamil. In: Römpp Online . Georg Thieme Verlag, accessed on September 17, 2011.

↑ ^a ^b ^c ^d ^e ^f ^g Entry on Gallopamil. In: Römpp Online . Georg Thieme Verlag, accessed on September 17, 2011.
↑ Data sheet (±) -Methoxyverapamil hydrochloride, ≥98% from Sigma-Aldrich , accessed on February 15, 2013 ( PDF ).
↑ Gross AS, Eichelbaum M, Mörike K, Mikus G: Pharmacokinetics and pharmacodynamics of R- and S-gallopamil during multiple dosing . In: British Journal of Clinical Pharmacology . 49, No. 2, February 2000, pp. 132-138. PMID 10671907 . PMC 2014898 (free full text).