Gerhard Artmann

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Gerhard Michael Artmann (* 1951 in Uder ) is a German physicist, professor of medical physics and applied biophysics and author .

Life

After attending the Johann-Georg-Lingemann-Gymnasium in Heiligenstadt in the GDR , Artmann studied physics at the TU Dresden from 1970 to 1974 , a. a. with Peter Paufler , Gustav Ernst Robert Schulze , Alfred Recknagel and Blau Solid-state physics, metal physics and X-ray methods of crystal physics. He then worked in potash mining, also underground, on a rock mechanical deformation measurement method patented by him. After a brief industrial position in medical technology in Leipzig, from 1980 he worked as a research assistant in the central workshop for scientific device construction of the Institute for Physiology at the Karl Marx University in Leipzig . From July 1983 to February 1984 Artmann was imprisoned for refusing to serve in the arms, including three months in solitary confinement in the Roter Ochse JVA . He was then transferred internally to cardiac surgery as an assistant in the field of medicine. At the end of 1984 he submitted an application to leave the Federal Republic of Germany .

At the end of 1985 he moved to the West with his wife and two eight and twelve year old children after 36 hours' notice. From 1986 to 1988 he did his doctorate at RWTH Aachen University on the subject of monolayer photometry for quantifying the shape and induced shape changes in human erythrocytes . In 1982/83, Henner Krug was the sponsor and co-inventor of Artmann's “Monolayer Technology” . Reporters at RWTH Aachen University on the doctoral thesis in physics were Hans Lüth and Holger Schmid-Schönbein after Artmann's departure to the Federal Republic of Germany .

In 1989 Artmann won the prize of the German Society for Biomedical Technology for the best dissertation in the German-speaking area. He owed him the start of a professorship at the FH Aachen on October 1, 1989. Between 1994 and 2002 he researched a total of about three years at the University of California, San Diego with Shu Chien and attended research seminars with Yuan-Cheng Fung . From 1994 to 1998 he did his habilitation externally at the Technical University of Ilmenau with the habilitation thesis Methodical and experimental contributions to the analysis of the resting form, the deformation and the integrity of human erythrocytes.

In his later biophysical research he found that the asymmetrical distribution of membrane lipids is reversibly changed by micropipette aspiration when the mechanical membrane tension in red blood cells is increased. A fundamental biophysical discovery was the temperature transition of hemoglobin in human erythrocytes at body temperature. The effect was discovered by him with micropipette experiments and later confirmed by him, Ilya Digel and Andreas Stadler together with their biophysics professor friend, Georg Büldt and Joe Zaccai from ILL Grenoble, with neutron scattering experiments . The temperature transition is linked to the body temperature of many animal species in a highly significant manner, so that hemoglobin can also be understood as a sensor of body temperature. His invention of the CellDrum technology is of great importance for pharmacological-toxicological and biological-medical research. It can be used to routinely measure the smallest cell forces, especially of in vitro autonomously beating heart cells, in cell cultures. The method is very suitable for pharmaceutical research and toxicology, in particular research into heart drugs. The CellDrum technology is being further developed by his group at the Institute for Neurophysiology at the University of Cologne under Jürgen Hescheler for the routine high-throughput measurement of human IPS - cardiomyocytes for pharmacology, toxicology and personalized medicine. In 2015 he received the Vordenker Award at the lateral thinker competition for his invention of a laboratory heart .

Artmann worked for over 25 years at the FH Aachen on the campus in Jülich . In 2008 he founded the Institute for Bioengineering at the FH Aachen / Campus Jülich. Due to his retirement in March 2017, he gave up the position and has been an external institute member since then. He is the spokesman for the bioengineering competence platform at the FH Aachen. Artmann has been working as a visiting professor at the Institute for Neurophysiology at the University of Cologne since March 2017 and is setting up a bioengineering group for stem cell research. He also edited with co-editors and professors Ilya Digel, Azhar Zhubanova and Aysegül Artmann, another specialist book Biological, Physical and Technical Basics of Cell Engineering .

In addition to his professional obligations, Artmann writes and publishes socially critical novels, poems and short stories.

Fonts (selection)

Specialist literature

  • Monolayer photometry to quantify the shape and induced shape changes of human erythrocytes. Diss. RWTH Aachen 1988, OCLC 721596509 .
  • Methodical and experimental contributions to the analysis of the resting form, the deformation and the integrity of human erythrocytes. Habilitation TU Ilmenau 1999 ( deutsche-digitale-bibliothek.de ).
  • Gerhard Artmann, Shu Chien: Bioengineering in Cell and Tissue Research. Springer-Verlag, Berlin 2008, ISBN 978-3-540-75409-1 .
  • Gerhard M. Artmann, Stephen Minger, Jürgen Hescheler: Stem Cell Engineering. Springer-Verlag, Berlin 2014, ISBN 978-3-642-44845-4 .
  • Gerhard M. Artmann, Aysegül Artmann, Azhar A. Zhubanova, Ilya Digel: Biological, Physical and Technical Basics of Cell Engineering. Springer Nature Verlag Pte Ltd, Singapore 2018, ISBN 978-981-10-7903-0 .

Fiction

literature

Web links

Individual evidence

  1. ^ Alfred Recknagel and the reconstruction of Dresden physics. Accessed April 21, 2018 (German).
  2. Gerhard M. Artmann: Monolayer photometry for quantifying the shape and induced changes in shape of human erythrocytes . 1988, OCLC 721596509 .
  3. Gerhard M. ArtmannShu Chien: bioengineering in Cell and Tissue Research . Springer-Verlag, Berlin / Heidelberg 2008, ISBN 978-3-540-75408-4 , doi : 10.1007 / 978-3-540-75409-1 .
  4. GM Artmann, KL Sung, T. Horn, D. Whittemore, G. Norwich, S. Chien: Micropipette aspiration of human erythrocytes induces echinocytes via membrane phospholipid translocation . In: Biophysical Journal . tape 72 , no. 3 , March 1997, ISSN  0006-3495 , pp. 1434–1441 , doi : 10.1016 / S0006-3495 (97) 78790-3 , PMID 9138589 , PMC 1184526 (free full text).
  5. AM Stadler, I. Digel, JP Embs, T. Unruh, M. Tehei, G. Zaccai, G. Büldt, GM Artmann: From powder to solution: hydration dependence of human hemoglobin dynamics correlated to body temperature . In: Biophysical Journal . tape 96 , no. 12 . Elsevier, June 17, 2009, ISSN  1542-0086 , p. 5073-5081 , doi : 10.1016 / j.bpj.2009.03.043 , PMID 19527667 , PMC 2712052 (free full text).
  6. a b G. M. Artmann, Ch. Kelemen, D. Porst, G. Büldt, Shu Chien: Temperature Transitions of Protein Properties in Human Red Blood Cells . In: Biophysical Journal . tape 75 , no. 6 , p. 3179-3183 , doi : 10.1016 / s0006-3495 (98) 77759-8 .
  7. GM Artmann, Ilya Digel, KF Zerlin, Ch Maggakis-Kelemen, Pt Linder: Hemoglobin senses body temperature . In: European Biophysics Journal . tape 38 , no. 5 , June 1, 2009, ISSN  0175-7571 , p. 589-600 , doi : 10.1007 / s00249-009-0410-8 .
  8. ^ Andreas M. Stadler, Jan P. Embs, Ilya Digel, Gerhard M. Artmann, Tobias Unruh: Cytoplasmic Water and Hydration Layer Dynamics in Human Red Blood Cells . In: Journal of the American Chemical Society . tape 130 , no. 50 , December 17, 2008, ISSN  0002-7863 , p. 16852–16853 , doi : 10.1021 / ja807691j .
  9. ^ Ilya Digel: Primary Thermosensory Events in Cells . In: Transient Receptor Potential Channels (=  Advances in Experimental Medicine and Biology ). Springer, Dordrecht, 2011, ISBN 978-94-007-0264-6 , pp. 451-468 , doi : 10.1007 / 978-94-007-0265-3_25 .
  10. GM Artmann, Ilya Digel, KF Zerlin, Ch Maggakis-Kelemen, Pt Linder: Hemoglobin senses body temperature . In: European Biophysics Journal . tape 38 , no. 5 , June 1, 2009, ISSN  0175-7571 , p. 589-600 , doi : 10.1007 / s00249-009-0410-8 .
  11. ^ Artmann, Gerhard M., Chien, Shu .: Bioengineering in cell and tissue research . Springer, Berlin 2008, ISBN 978-3-540-75409-1 .
  12. J. Trzewik, A. Artmann-Temiz, PT Linder, T. Demirci, I. Digel: Evaluation of lateral mechanical tension in thin-film tissue constructs . In: Annals of Biomedical Engineering . tape 32 , no. 9 , September 2004, ISSN  0090-6964 , p. 1243-1251 , PMID 15495361 .
  13. P. Linder, J. Trzewik, M. Rüffer, GM Artmann, I. Digel: Contractile tension and beating rates of self-exciting monolayers and 3D tissue constructs of neonatal rat cardiomyocytes . In: Medical & Biological Engineering & Computing . tape 48 , no. 1 , January 1, 2010, ISSN  0140-0118 , p. 59 , doi : 10.1007 / s11517-009-0552-y .
  14. ^ Matthias Goßmann, Ralf Frotscher, Peter Linder, Stephan Neumann, Robin Bayer: Mechano-Pharmacological Characterization of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells . In: Cellular Physiology and Biochemistry . tape 38 , no. 3 , p. 1182-1198 , doi : 10.1159 / 000443124 .
  15. Jürgen Hescheler: Alumnus of the month at Jugend forscht . In: Deutsches Ärzteblatt . ( aerzteblatt.de [accessed on September 16, 2017]).
  16. Biological, Physical and Technical Basics of Cell Engineering | SpringerLink . doi : 10.1007 / 978-981-10-7904-7 ( springer.com [accessed April 21, 2018]).
  17. Panta rhei - Our blood, our heart - The CellDrum technology. submitted by Gerhard M. Artmann.
  18. aachener-zeitung.de
  19. Eichsfelder received the Querdenker Award. In: Thuringian General. December 9, 2015.
  20. Gerhard M. Artmann, Aysegül Artmann, Azhar Zhubanova, Ilya Digel: Biological, physical and technical basics of cell engineering . Singapore 2018, ISBN 978-981-10-7903-0 , doi : 10.1007 / 978-981-10-7904-7 .
  21. Artmann, Gerhard, 1951-: Zwischenland: Erzählung . 1st edition Kiepenheuer, Leipzig 1991, ISBN 978-3-378-00452-8 .
  22. ^ Artmann, Gerhard M. 1951-: Final words of a German to his master poem . Ed. Fischer, Frankfurt, M 2010, ISBN 978-3-89950-513-9 .
  23. Artmann, Gerhard: Hello Ann . 1st edition Books on Demand, Norderstedt 2014, ISBN 978-3-7357-1364-3 .