Hans-Peter Hauri

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Hans-Peter Hauri (2008)

Hans-Peter Hauri (born February 13, 1945 in Zurich ) is a Swiss biologist .

Life

Hans-Peter Hauri, emeritus professor of cell biology , conducted research from 1983 to 2010 at the Biozentrum of the University of Basel . After studying biology at the University of Zurich , he received his doctorate there in 1973 and then worked at the Pediatric Clinic of the University Hospital Bern . In 1978 he moved to Massachusetts General Hospital at Harvard University in Boston as a postdoctoral fellow . In 1980 he returned to Switzerland and did research in the group of Urs A. Meyer at the University of Zurich and later at the Biozentrum. Here he was appointed professor of cell biology in 1992 and full professor in 2004. In addition, he was head of studies for the biology curriculum and dean of the Faculty of Science at the University of Basel.

Act

Hans-Peter Hauri researched the secretion of proteins , how they get from the place of synthesis to their destination while maintaining the integrity of the cell organelles . Among other things, Hauri has discovered that the membrane protein CLIMP-63 mediates the interaction between the endoplasmic reticulum (ER) and microtubules . In addition, he was able to establish the ER- Golgi intermediate compartment (ERGIC) as a new cell organelle of the secretion pathway. Secretory proteins, which are produced in the ER, enter the Golgi apparatus via ERGIC. With a screening method he developed, it was possible for the first time to systematically record protein interactions in the secretion pathway of living cells. He also established signal networks for the secretion process.

membership

  • American Society for Cell Biology

Publications

  • A. Schweizer, JA Fransen, T. Bachi, L. Ginsel, HP Hauri: Identification, by a monoclonal antibody, of a 53-kd protein associated with a tubulo-vesicular compartment at the cis-side of the Golgi apparatus. In: J Cell Biol 107, 1988, pp. 1643-1653, PMID 3182932 .
  • K. Matter, M. Brauchbar, K. Bucher, HP Hauri: Sorting of endogenous plasma membrane proteins occurs from two sites in cultured human intestinal epithelial cells (Caco-2). In: Cell 60, 1990, pp. 429-437, PMID 2302734 .
  • C. Appenzeller, H. Andersson, F. Kappeler, HP Hauri: The lectin ERGIC-53 is a transport receptor for glycoproteins. In: Nat Cell Biol . 1, No. 6, 1999, pp. 330-334, PMID 10559958 .
  • B. Nyfeler, V. Reiterer, MW Wendeler, E. Stefan, B. Zhang, SW Michnick, HP Hauri: Identification of ERGIC-53 as an intracellular transport receptor for alpha1-antitrypsin. In: J Cell Biol 180, 2008, pp. 705-712, PMID 18283111 .
  • H. Farhan, MW Wendeler, S. Mitrovic, E. Fava, Y. Silberberg, R. Sharan, M. Zerial, HP Hauri: MAPK signaling to the early secretory pathway revealed by kinase / phosphatase functional screening. In: J Cell Biol 189, 2010, pp. 997-1011, PMID 20548102 .

Web link

Individual evidence

  1. ↑ Hans-Peter Hauri in the research database of the Swiss National Fund, snf.ch, accessed November 18, 2014.
  2. ↑ Emeriti , unibas.ch, accessed on November 18, 2014.
  3. ↑ New method for studying protein secretion developed , unibas.ch, accessed on November 18, 2014.
personal data
SURNAME Hauri, Hans-Peter
BRIEF DESCRIPTION Swiss biologist
DATE OF BIRTH February 13, 1945
PLACE OF BIRTH Zurich