Holger Christiansen

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Holger Christiansen (born March 7, 1957 in Hemmingstedt , Dithmarschen ) is a German pediatrician , oncologist , hematologist , cancer researcher and university professor .

Life

Holger Christiansen graduated from the school of scholars in Meldorf in 1976 . He studied human medicine at the Justus Liebig University in Giessen . This was followed by training as a specialist in pediatric and adolescent medicine at the University Children's Clinic in Gießen , followed by further training in pediatric hematology and oncology in the independent department for pediatric oncology and hematology at the University Children's Hospital in Gießen under the direction of Fritz Lampert .

From 1987 to 1989 he was a fellow of the German Research Foundation ( DFG ) in the Collaborative Research Center 215 with the project: Cytogenetics and Molecular Biology of Neuroblastoma . In 1988 he became a Inauguraldissertation on chromosome aberrations and oncogene - amplification in neuroblastoma doctorate . He received his habilitation in 1995 with work on tumor cell genetic properties and their clinical significance in neuroblastoma and received the venia legendi in paediatrics at the Justus Liebig University in Gießen in 1996 .

In 1996 he moved to the University Children's Clinic in Marburg and headed the Pediatric Oncology and Hematology department as senior physician. In 2003 he was appointed adjunct professor at the Philipps University in Marburg . In 2009 he was offered the professorship for pediatric and adolescent medicine with a focus on oncology, hematology and hemostaseology at the University of Leipzig , combined with the management of the independent department for pediatric oncology, hematology and hemostaseology in the department for gynecology at the university hospital in Leipzig .

Awards

  • In 1989 the Justus Liebig University in Giessen awarded him the prize for the best dissertation of the academic year 1988/89 in the field of human medicine.
  • In 1993 he received the 1993 advancement award from the Society for Pediatric Oncology and Hematology (GPOH).
  • In 1995, his research on neuroblastoma was honored with the 1994 Kind-Philipp Foundation's Science Prize.

Publications (excerpt)

  • H. Christiansen, F. Lampert: Tumor karyotype discriminates between good and bad prognostic outcome in neuroblastoma . In: Br J Cancer , 57, 1988, pp. 121-126, PMID 3348945 .
  • H. Christiansen, NM Christiansen, F. Wagner, M. Altmannsberger, F. Lampert: Neuroblastoma: inverse relationship between expression of N-myc and NGF-r . In: Oncogene , 5, 1990, pp. 437-440, PMID 2156211 .
  • H. Christiansen, J. Schestag, NM Christiansen, KH Grzeschik, F. Lampert: Clinical impact of chromosome 1 aberrations in neuroblastoma: a metaphase and interphase cytogenetic study . In: Genes, Chromosomes & Cancer , 5, 1992, pp. 141-149, PMID 1381950 .
  • HJ Terpe, H. Christiansen, F. Berthold et al .: Absence of CD44-standard in human neuroblastoma correlates with histological dedifferentiation, N-myc amplification and reduced survival probability . In: Cell Death Differ , 1, 1994, pp. 123-128, PMID 17180025 .
  • C. Brinkschmidt, H. Christiansen, HJ Terpe et al .: Comparative genomic hybridization (CGH) analysis of neuroblastomas - an important methodological approach in pediatric tumor pathology . In: J Pathol , 181, 1997, pp. 394-400, PMID 9196436 .
  • N. Bown, S. Cotterill, M. Lastowska et al .: Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma . In: N Engl J Med , 340, 1999, pp. 1954-1961, PMID 10379019 .
  • E. Bergmann, M. Wanzel, A. Weber, I. Shin, H. Christiansen, M. Eilers: Expression of P27 (KIP1) is prognostic and independent of MYCN amplification in human neuroblastoma . In: Int J Cancer , 95, 2001, pp. 176-183, PMID 11307151 .
  • B. Berwanger, O. Hartmann, E. Bergmann et al .: Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma . In: Cancer Cell , 2, 2002, pp. 377-386, PMID 12450793 .
  • A. Weber, P. Imisch, E. Bergmann, H. Christiansen: Coamplification of DDX1 correlates with an improved survival probability in children with MYCN-amplified human neuroblastoma . In: J Clin Oncol , 22, 2004, pp. 2681-2690, PMID 15226335 .
  • A. Weber, J. Marquardt, D. Elzi et al .: Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation . In: EMBO J , 27, 2008, pp. 1563-1574, PMID 18451802 .
  • T. Otto, S. Horn, M. Brockmann et al .: Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma . In: Cancer Cell , 6, 2009, pp. 67-78, PMID 19111882 .
  • A. Weber, S. Taube, S. Starke, E. Bergmann, N. M. Christiansen, H. Christiansen: Detection of human tumor cells by amplicon fusion site polymerase chain reaction (AFS-PCR) . In: J Clin Invest , 121, 2011, pp. 545-553, PMID 21293059 .
  • E. Berger, R. Soldati, N. Huebener et al .: Salmonella SL7207 application is the most effective DNA vaccine delivery method for successful tumor eradication in a murine model for neuroblastoma . In: Cancer Lett , 331, 2013, pp. 167-173, PMID 23337288 .

Web links

Individual evidence

  1. ^ Society for Pediatric Oncology and Hematology (GPOH). Retrieved December 10, 2013 .
  2. ^ Kind-Philipp-Foundation. Retrieved December 11, 2013 .
personal data
SURNAME Christiansen, Holger
BRIEF DESCRIPTION German pediatrician, oncologist, hematologist, cancer researcher and university professor
DATE OF BIRTH March 7, 1957
PLACE OF BIRTH Hemmingstedt , Dithmarschen