Hyperaldosteronism
| Classification according to ICD-10 | |
|---|---|
| E26 | Hyperaldosteronism |
| ICD-10 online (WHO version 2019) | |
Hyperaldosteronism or aldosteronism is a disease in which the steroid hormone aldosterone is produced in abundance, which means that too much salt (especially sodium salt) is retained in the body and more potassium is excreted. This can lead to changes in the acidity in the blood as well as muscle weakness, muscle cramps and sensory disturbances and cardiac arrhythmias.
A distinction is made between different forms: In primary hyperaldosteronism ( Conn syndrome ), too much aldosterone is formed through a process in the adrenal cortex (idiopathic bilateral hyperplasia in over 70% of cases , an adenoma in less than 30% of cases , and very rarely others Causes such as carcinoma or genetic defects ).
The secondary hyperaldosteronism has a very different origin and occurs at very different frequencies on. Here, due to higher-level regulatory mechanisms, an increased formation of aldosterone is initiated or - as in the case of liver cirrhosis - the breakdown is slowed down.
There is also pseudohyperaldosteronism .
Clinically, arterial hypertension (increased blood pressure) and possibly hypokalaemia are in the foreground in primary hyperaldosteronism, and edema and ascites in the secondary form . Hyperaldosteronism is treated with aldosterone antagonists ( e.g. spironolactone or eplerenone ) or, in the primary form, by surgical removal of the affected adrenal gland (adrenalectomy) if an adenoma or carcinoma is detectable.
In the context of the primary hyperaldosteronism hereditary forms are distinguished from those of the family type I by a fusion of the CYP11B1 - and CYP11B2 - genes is caused.
Web links
- Medical info : hyperaldosteronism .
Individual evidence
- ↑ I. Quack, O. Vonend, LC Rump: Familial Hyperaldosteronism I-III . In: Horm Metab Res . February 2010, doi : 10.1055 / s-0029-1246187 , PMID 20131203 .
