Islet cell adenoma
| Classification according to ICD-10 | |
|---|---|
| D13.7 | Benign neoplasm of the endocrine gland in the pancreas |
| ICD-10 online (WHO version 2019) | |
The islet cell adenoma (syn. Nesidiom, Nesidioblasto, Adenoma insulocellulare) is a very rare, benign tumor of the islet organ of the pancreas. It can come from different cell types. It is usually hormonally active and then causes corresponding clinical symptoms . Tumors with a lack of hormonal activity (clinically silent) are found in some cases as a mere chance finding in about one in a hundred autopsies .
Use of the term
The term "islet cell adenoma " basically refers to a benign tumor from the group of gastroenteropancreatic neuroendocrine tumors (type 1a) .
The dignity (whether benign or malignant) of tumors of the islet organ can, however, ultimately only be definitively determined in terms of malignancy when metastases occur. It is therefore suggested to use the neutral term “islet cell tumors” for tumors of this origin. Proven malignant tumors of this origin are referred to as islet cell carcinomas.
Systematics
The islet cell adenomas include the insulinoma (originating from the β islet cells, therefore producing insulin ), the glucagonoma (originating from the α islet cells, therefore producing glucagon ) and the gastrinoma ( gastrin- producing tumor that is located in the pancreas in 80% of all cases and cause of Zollinger-Ellison syndrome ). The VIP- producing form is also referred to as Vipom (Syn. VIPom, D1 tumor - is the cause of Verner-Morrison syndrome ). Islet cell adenomas are classified as "neuroendocrine tumors" (GEP-NET - gastroenteropancreatic neuroendocrine tumor).
Remarks
Islet cell adenomas are very rare, their incidence is less than 1: 100,000. In general autopsy material, it is 0.4–1.5%. In the literature, the generic term islet cell adenoma is used synonymously with insulinoma in some cases . Islet cell adenomas can occur as part of multiple endocrine neoplasia type 1 .
Individual evidence
- ↑ a b P. Reuter: Springer Large Dictionary Medicine. Springer, 2005, ISBN 3-540-21352-X , p. 437. (online at: books.google.de )
- ↑ a b C. Thomas: Histopathology. Schattauer Verlag, 2006, ISBN 3-7945-2429-2 , p. 279. (online at: books.google.de )
- ↑ a b M. Lohr et al .: Internal medicine. Urban & Fischer-Verlag, 2005, ISBN 3-437-42451-3 , p. 392. (online at: books.google.de )
- ↑ S. Bogensberger: Hexal Pocket Lexicon Medicine. Urban & Fischer-Verlag, 2004, ISBN 3-437-15011-1 , p. 359. (online at: books.google.de )
- ↑ a b G. Feichter among others: Zytopathologie. Springer, 2000, ISBN 3-540-66502-1 , p. 278. (online at: books.google.de )
- ↑ a b A. Brochert: Surgery from case to case. Urban & Fischer-Verlag, 2005, ISBN 3-437-43971-5 , p. 28. (online at: books.google.de )
