Jan Peutz

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Johannes "Jan" Laurentius Augustinus Peutz (born March 24, 1886 in Uithuizen , † December 20, 1957 in The Hague ) was a Dutch internist . In 1921 he published the first description of the polyposis, later referred to as Peutz-Jeghers syndrome , with hyperpigmentation of the lip and oral mucosa.

Life

Peutz studied medicine at the Universities of Groningen and Utrecht . After graduating in 1914, he worked as an assistant doctor in Rotterdam and at clinics in Germany, Italy and Belgium. In 1917 he moved to The Hague to the Catholic Hospital St. Joannes de Deo , where he later headed the Clinic for Internal Medicine. He received his doctorate from Utrecht University in 1921 . In 1951 he retired. He was married and had one son.

Act

In 1921 Peutz published the first description of the polyposis, later referred to as Peutz-Jeghers syndrome , with hyperpigmentation of the lip and oral mucosa. He had noticed this hyperpigmentation in two adolescent patients in the course of 1920. It turned out to be brothers. The older brother had to undergo an operation due to an intestinal obstruction (ileus). Polyps with suspicious malignancy were found in the resected tissue . Other siblings were affected by hyperpigmentation and polyposis, and two siblings also had nasal polyps .

Other cases of the syndrome were described by Harold Jeghers and colleagues in 1949 . Peutz 'pupil van Wijk received his doctorate in 1950 with a doctorate on "Peutz disease", the term "Peutz-Jeghers syndrome" was introduced in 1954 by Bruwer.

The family of the cases presented in the first description ("Harrisburg family") remained under observation for subsequent generations.

Awards

Jan Peutz was awarded the Cross of Honor Pro Ecclesia et Pontifice , the Order of Gregorius (Commander) and the Order of Orange-Nassau (Officer).

Fonts (selection)

  • JLA Peutz: Over een zeer merkwaardige, combinederde familiaire polyposis van de slijmvliezen van den tractus intestinalis met die van de neuskeelholte en gepaard met peculiar pigmentaties van huid en slijmvliezen. In: Nederlandsch Maandschrift voor Geneeskunde. 1921, number 10, pp. 134-146. ( Full text ; PDF; 1.6 MB)

literature

Individual evidence

  1. ↑ a b Th. W. van Wijk: In memoriam Dr. Johannes Laurentius Augustinus Peutz . In: Nederlands Tijdschrift voor Geneeskunde. 1958, number 102, pp. 404-405.
  2. ↑ a b c J. J. Keller et al .: Jan Peutz, Harold Jeghers and a remarkable combination of polyposis and pigmentation of the skin and mucous membranes. In: Familial cancer. Volume 1, Number 3-4, 2001, pp. 181-185, ISSN  1389-9600 . PMID 14574176 .
  3. ↑ JLA Peutz: Klinische en experimentaleele bijdrage tot de diagnostiek en internal therapy van pancreas stoornissen en met bijzondere betrekking tot de diabetes . The Hague 1921.
  4. ↑ JLA Peutz: Over een zeer merkwaardige, gecombineerde familiaire polyposis van de slijmvliezen van den tractus intestinalis met die van de neuskeelholte en gepaard met peculiar pigmentaties van huid en slijmvliezen. In: Nederlandsch Maandschrift voor Geneeskunde. 1921, number 10, pp. 134-146. ( Full text ( Memento of the original from June 20, 2013 in the Internet Archive ) Info: The archive link has been inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this note .; PDF; 1.6 MB) @1@ 2Template: Webachiv / IABot / jeghers.com
  5. ^ GJ Offerhaus et al .: Biographical sketch of Jan Peutz. In: Gastroenterology. Volume 134, Number 5, May 2008, pp. 1628-1629, ISSN  1528-0012 . doi : 10.1053 / j.gastro.2008.03.067 . PMID 18471538 .
  6. ↑ M. Kopacova et al .: Peutz-Jeghers syndrome: diagnostic and therapeutic approach. In: World journal of gastroenterology: WJG. Volume 15, Number 43, November 2009, pp. 5397-5408, ISSN  1007-9327 . PMID 19916169 . PMC 2778095 (free full text).
  7. ^ A. Bruwer et al .: Surface pigmentation and generalized intestinal polyposis; (Peutz-Jeghers syndrome). In: Proceedings of the staff meetings. Mayo Clinic. Volume 29, Number 6, March 1954, pp. 168-171, ISSN  0092-699X . PMID 13145642 .
  8. ^ AM Westerman et al .: Peutz-Jeghers syndrome: 78-year follow-up of the original family. In: Lancet. Volume 353, Number 9160, April 1999, pp. 1211-1215, ISSN  0140-6736 . PMID 10217080 .
personal data
SURNAME Peutz, Jan
ALTERNATIVE NAMES Peutz, Johannes Laurentius Augustinus (full name)
BRIEF DESCRIPTION Dutch internist
DATE OF BIRTH March 24, 1886
PLACE OF BIRTH Uithuizen
DATE OF DEATH December 20, 1957
Place of death The hague