Jin-Quan Yu
Jin-Quan Yu (born January 10, 1966 in China ) is a Sino-American chemist (synthetic organic chemistry ).
Life
Jin-Quan Yu studied at East China Normal University with a bachelor's degree in 1987 and at the Gugangzhou Institute of Chemistry with a master's degree in 1990. He received his doctorate from Cambridge University with Jonathan Spencer in 1999 , where he was a research fellow from 1998 and Became a faculty member in 2003 (as a Royal Society Research Fellow). In 2001/02 he was a post-doctoral student at Harvard University with Elias J. Corey and from 2004 to 2007 he was an assistant professor at Brandeis University . He then became Associate Professor and 2010 Professor (from 2012 Frank and Bertha Hupp Professor ) at the Scripps Research Institute in La Jolla .
plant
He deals with synthetic methods and the development of metal-based catalysts - especially those based on palladium or copper - for CH activation (breaking the CH bond in hydrocarbons for the addition of new functional groups). The catalysts are passed through functional groups and ligands to intermediate stages of the synthesis (directing groups), which are removed again in the end product. His group was able to significantly expand the distance between these functional groups and the activated CH bond and they developed modified amino acids as transient directing groups for a series of ketones and aldehydes that automatically attach to the target molecules and then dissolve again and which can be reused. The synthesis can also be designed enantioselectively , which is of central importance for biologically active molecules. The aim is the more efficient and cheaper synthesis of bioactive substances, for example for pharmaceuticals.
Recently he succeeded in activating methylene groups with palladium catalysts with ligands based on (chiral) amino acids and quinolines , whereby an enantioselective synthesis could also be achieved. That was seen as a big breakthrough.
In 2008 Yu Sloan was a fellow , in 2012 he was an ACS Cope Scholar and in the same year he received the Mukaiyama Award from the Japanese Society of Organic Synthesis, the Bristol-Myers Squibb Award and in 2011 the Novartis Early Career Award in organic chemistry. In 2012 he became a Fellow of the Royal Society of Chemistry and the American Association for the Advancement of Science . In 2013 he received the Sackler Prize and in 2014 the Elias J. Corey Award from the ACS. In 2016 he became a MacArthur Fellow . In 2019, Yu was elected to the American Academy of Arts and Sciences .
Fonts
- with Xiao Chen, Keary M Engle, Dong-Hui Wang: Palladium (II) -Catalyzed CH Activation / CC Cross-Coupling Reactions: Versatility and Practicality, Angewandte Chemie Internat. Edition, Volume 48, 2009, pp. 5094-5115 (German version: Palladium (II) -catalyzed CH activation / CC cross-coupling: Versatility and Applicability, Angewandte Chemie, Volume 121, 2009, p. 5196)
- with Keary M Engle, Tian-Sheng Mei, Masayuki Wasa: Weak coordination as a powerful means for developing broadly useful C – H functionalization reactions, Accounts of Chemical Research, Volume 45, 2011, pp. 788-802
- with DH Wang, KM Engle, BF Shi: Ligand-enabled reactivity and selectivity in a synthetically versatile aryl C – H olefination, Science, Volume 327, 2010, pp. 315-319
- with Dasheng Leow, Gang Li, Tian-Sheng Mei: Activation of remote meta-CH bonds assisted by an end-on template, Nature, Volume 486, 2012, pp. 518-522
- with R Giri, BF Shi, KM Engle, N Maugel, JQ Yu: Transition metal-catalyzed C – H activation reactions: diastereoselectivity and enantioselectivity, Chemical Society Reviews, Volume 38, 2009, pp. 3242-3272
- with Ling Chu, Kai-Jiong Xiao: Room-temperature enantioselective C – H iodination via kinetic resolution, Science, Volume 346, 2014, pp. 451–455
- with Gang Chen, Wei Gong, Zhe Zhuang, Michal S. Andra, Yan-Qiao Chen, Xin Hong, Yun-Fang Yang, Tao Liu, KN Houk: Ligand-Accelerated Enantioselective Methylene C (sp3) -H Bond Activation, Science, Volume 353, 2016, p. 1023
- with Fang-Lin Zhang, Kai Hong, Tuan-Jie Li, Hojoon Park: Functionalization of C (sp3) -H bonds using a transient directing group, Science, Volume 351, 2016, p. 252
swell
- Author profile Jin-Quan Yu . In: Angewandte Chemie . tape 123 , no. 22 , 23 May 2011, p. 5118-5118 , doi : 10.1002 / anie.201101811 .
- Biography at the Scripps Institute
Individual evidence
| personal data | |
|---|---|
| SURNAME | Yu, Jin-Quan |
| BRIEF DESCRIPTION | Chinese-American chemist |
| DATE OF BIRTH | January 10, 1966 |
| PLACE OF BIRTH | China |