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Joffe or Joffé is the family name of the following people:
- Abraham Z. Joffe (1909-2000), Israeli mycologist and mycotoxologist
- Abram Fjodorowitsch Joffe (1880–1960), Soviet physicist
- Adolf Abramowitsch Joffe (1883–1927), Soviet-Russian revolutionary
- Alex Joffé (1918–1995), French film director, screenwriter and actor
- Avraham Joffe (1913–1983), Israeli general
- Boris Lasarewitsch Joffe (* 1926), Russian physicist
- Carol Joffe , production designer
- Charles H. Joffe (1929–2008), American artist agent and film producer
- George Joffé (* 1940), British geographer
- Gideon Joffe (* 1972), German management consultant, entrepreneur and chairman of the Berlin Jewish Community
- Joel Joffe (Joel Goodman Joffe, Baron Joffe of Liddington; 1932-2017), South African Labor Party politician and human rights lawyer
- Josef Joffe (* 1944), German journalist
- Nadeschda Adolfowna Joffe (1906–1999), Soviet Trotskyist
- Roland Joffé (* 1945), French-British film director
- Rowan Joffe (* 1973), British screenwriter and film director
- Ud Joffe (* 1967), Israeli conductor
See also:
- Alexander Ioffe (* 1938), Soviet-Israeli mathematician and engineer
- Joffe Prize , Science Prize
- Joffe Institute , research institute in Saint Petersburg
- Boris Yoffe (* 1968), Russian-German composer
- Ioffe