Kasugamycin
Structural formula | ||||||||||||||||
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General | ||||||||||||||||
Surname | Kasugamycin | |||||||||||||||
other names |
3- O - [2-Amino-4 - [(carboxyiminomethyl) amino] -2,3,4,6-tetradeoxy- D -arabino-hexopyranosyl] - D - chiro- inositol |
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Molecular formula | C 14 H 25 N 3 O 9 | |||||||||||||||
Brief description |
White dust |
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External identifiers / databases | ||||||||||||||||
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Drug information | ||||||||||||||||
Drug class | ||||||||||||||||
Mechanism of action |
Protein synthesis inhibitor |
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properties | ||||||||||||||||
Molar mass | 379.37 g mol −1 | |||||||||||||||
Physical state |
firmly |
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Melting point |
decomposes between 218 and 230 ° C |
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safety instructions | ||||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Kasugamycin is an aminoglycoside - antibiotic , consisting of Streptomyces kasugaensis was isolated. Kasugamycin works by inhibiting the 50S subunit of bacterial ribosomes and thus protein biosynthesis . It was found in 1965 by Hamao Umezawa , who also discovered kanamycin and bleomycin .
use
Kasugamycin is used in rice, potato, pepper and tomato growing. It is used to combat Erwinia atroseptica and Cladosporium fulvum in tomato cultivation and Xanthomonas campestris pv. Vesicatoria in tomato and paprika cultivation. The compound has strong preventive effects on Pyricularia oryzae .
Admission
No plant protection products containing this active ingredient are permitted in the EU or Switzerland .
Individual evidence
- ↑ a b c data sheet Kasugamycin hydrochloride from Streptomyces kasugaensis, ≥90% (HPLC) from Sigma-Aldrich , accessed on January 14, 2015 ( PDF ).
- ↑ Entry on kasugamycin. In: Römpp Online . Georg Thieme Verlag, accessed on January 14, 2015.
- ↑ Patent US3358001 : Antibiotic kasugamycin. Published December 12, 1967 , Inventors: Umezawa Hamao, Okami Yoshiro, Takenchi Tomio, Hamada Masa.
- ↑ EPA Pesticide Fact Sheet: Kasugamycin , September 2005.
- ↑ Yasuji Suhara, Kenji Maeda, Hamao Umezawa, Masaji Ohno: Chemical studies on kasugamycin. V. The structure of kasugamycin . In: Tetrahedron Letters . tape 7 , no. January 12 , 1966, p. 1239–1244 , doi : 10.1016 / s0040-4039 (01) 99701-1 (English, PDF ).
- ^ Directorate-General for Health and Food Safety of the European Commission: Entry on kasugamycin in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; accessed on March 26, 2016.