Compensation (medicine)
Under compensation of Latin compensatio "balance", "Spare", is understood in the clinical medicine to compensate an abnormal state by a change of another state.
If this compensation is no longer possible, decompensation occurs .
The compensation is:
- the compensation of a reduced performance through increased activity, e.g. B. ventricular hypertrophy in heart valve defects ,
- the compensation of a (partial) organ failure or an absence through increased growth, for example in hypertrophy, z. B. in a unilateral renal agenesis the excessive growth of the single kidney
- the adaptation to a disturbed function by counter-regulation, e.g. B. in the reduction of TSH in hyperthyroidism , in the Goldblatt effect in renal artery stenosis or after damage to the auditory or equilibrium organ
- the compensation of a misalignment by changing posture, e.g. B. on the spine in Scheuermann's disease
In human genetics , the term is used for a compensating and / or restoring mutation with partial or complete restoration of the function of a gene product that has become defective.
There are different forms:
- intragenic restoration as a reverse mutation
- intergenic compensatory mutation in another gene whose product works in conjunction with the first gene product
- Complementation
Individual evidence
- ↑ Entry on compensation in the Flexikon , a Wiki of the DocCheck company
- ↑ Willibald Pschyrembel : Clinical Dictionary , 266th, updated edition, de Gruyter, Berlin 2014, ISBN 978-3-11-033997-0 , keyword: compensation, page 1129.
- ↑ H. Yazdanshenas, A. Ashouri, G. Kaufman: Neurovestibular Compensation following Ototoxic Lesion and Labyrinthectomy. In: International archives of otorhinolaryngology. Vol. 20, No. 2, April 2016, pp. 114–123, doi: 10.1055 / s-0036-1572527 , PMID 27096015 , PMC 4835328 (free full text).