L- arginine: glycine amidinotransferase
Glycine amidinotransferase, mitochondrial | ||
---|---|---|
other names |
L- arginine: glycine amidinotransferase, transamidinase |
|
Properties of human protein | ||
Mass / length primary structure | 423 amino acids , 48,455 Da | |
Identifier | ||
External IDs | ||
Enzyme classification | ||
EC, category | 2.1.4.1 | |
Orthologue (human) | ||
Entrez | 2628 | |
Ensemble | ENSG00000171766 | |
UniProt | P50440 | |
Refseq (mRNA) | NM_001321015.1 | |
Refseq (protein) | NP_001307944.1 | |
PubMed search |
2628
|
L- arginine: glycine amidinotransferase (AGAT, EC ) is an enzyme that is involved in the synthesis of guanidinoacetate from the amino acids arginine and glycine , mainly in the kidneys and salivary glands.
properties
The L- arginine: glycine amidinotransferase catalyzes the following reaction:
L- arginine + glycine ↔ L- ornithine + guanidinoacetate
Guanidinoacetate is the direct precursor of creatine in the metabolism . The L- arginine: glycine amidinotransferase is produced in the brain , in the heart , in the kidneys (highest gene expression ), in the liver , in the lungs , in the salivary gland , in the placenta , in a fetus and in the skeletal muscles . The Michaelis-Menten constant is 2.0 µM for arginine, 3.0 µM for glycine and the maximum reaction rate is 0.44 µmol / min / mg enzyme.
Web links
Individual evidence
- ↑ ENZYME entry 2.1.4.1. Retrieved May 18, 2018 (American English).
- ↑ Prof. Blume's tip of the month. Retrieved May 18, 2018 .
- ↑ a b c d GATM - Glycine amidinotransferase, mitochondrial precursor - Homo sapiens (Human) - GATM gene & protein. In: uniprot.org. June 20, 2018, accessed May 23, 2018 .