Lathosterol oxidase
| Lathosterol oxidase | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 299 amino acids | |
| Secondary to quaternary structure | multipass membrane protein (ER) | |
| Cofactor | Fe | |
| Identifier | ||
| Gene name | SC5DL | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 1.14.21.6 , oxidoreductase | |
| Response type | Dehydration | |
| Substrate | Lathosterol + O 2 + NADPH / H + | |
| Products | 7-dehydrocholesterol + 2 H 2 O + NADP + | |
| Occurrence | ||
| Parent taxon | Eukaryotes | |
The lathosterol oxidase is the enzyme in eukaryotes that the dehydrogenation of sterols in the 5-position catalyzed . The reaction step is part of cholesterol biosynthesis . The transmembrane protein is located on the endoplasmic reticulum . In humans, mutations on SC5DL - gene , the cause of the rare hereditary disease Lathosterolose .
Catalyzed reaction
+ O 2 + NADP H / H + ⇒ 
+ 2 H 2 O + NADP +
Lathosterol is dehydrated to 7-dehydrocholesterol.
Individual evidence
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Cholesterol Biosynthesis - Learning and Teaching Materials
- D'Eustachio / reactome: Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol
- Orphanet: Lathosterolosis