Limbate toxin
Potassium channel toxin alpha-KTx 1.4 | ||
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other names |
Limbatotoxin, LbTx |
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Mass / length primary structure | 37 amino acids , 4,042 Da | |
Identifier | ||
External IDs |
Limbatus toxin (synonym Kaliumkanaltoxin alpha-KTx 1.4 , LbTx ) is a toxin from the scorpion Centruroides limbatus .
properties
Limbatus toxin is a protein and scorpion toxin . It binds and inhibits calcium- activated potassium channels of the maxi-K type . Limbatus toxin is structurally related to charybdotoxin a , charybdotoxin b , iberiotoxin and also with noxious toxin , margatoxin and tityus toxin Kα .
literature
- LD Possani, E. Merino, M. Corona, F. Bolivar, B. Becerril: Peptides and genes coding for scorpion toxins that affect ion channels. In: Biochemistry. Volume 82, Numbers 9-10, 2000 Sep-Oct, pp. 861-868, PMID 11086216 .
- SP Bush: Envenomation by the scorpion (Centruroides limbatus) outside its natural range and recognition of medically important scorpions. In: Wilderness & environmental medicine. Volume 10, Number 3, 1999, pp. 161-164, PMID 10560310 .
Web links
Individual evidence
- ^ OB McManus, LM Helms, L. Pallanck, B. Ganetzky, R. Swanson, RJ Leonard: Functional role of the beta subunit of high conductance calcium-activated potassium channels. In: Neuron. Volume 14, Number 3, March 1995, pp. 645-650, PMID 7695911 .
- ^ Hervé Rochat: Animal Toxins. Springer Science & Business Media, 2000, ISBN 978-3-764-35983-6 , p. 184.