Margatoxin

Potassium channel toxin alpha-KTx 2.2
	according to PDB 1MTX
other names	Margatoxin, MTx
Mass / length primary structure	39 amino acids , 4,185 Da
Identifier
External IDs	UniProt : P40755 ;

Margatoxin (synonym potassium channel blocker alpha-KTx 2.2 ) is a toxin from the scorpion Centruroides margaritatus .

properties

Margatoxin is a protein and scorpion toxin . It inhibits potassium channels such as B. Kv1.1 / KCNA1 ( IC ₅₀ = 0.144 nM , K _d = 4.2 nM), Kv1.2 / KCNA2 (IC ₅₀ = 0.675 nM, K _d = 6.4 pM), Kv1.3 / KCNA3 ( IC ₅₀ = 0.23 nM, K _d = 11.7 pM) and Shaker (Kd = 160 nM). Margatoxin is structurally related to Iberiotoxin and Noxiustoxin , it consists of an α-helix and a β-sheet of three strands. Compared to charybdotoxin a and b , the leaflet is slightly larger.

Web links

MeSH margatoxin

Individual evidence

↑ A. Bartok, A. Toth, S. Somodi, TG Szanto, P. Hajdu, G. Panyi, Z. Varga: Margatoxin is a non-selective inhibitor of human Kv1.3 K + channels. In: Toxicon: official journal of the International Society on Toxinology. Volume 87, September 2014, pp. 6-16, doi : 10.1016 / j.toxicon.2014.05.002 , PMID 24878374 .
↑ Rino Rappuoli: Guidebook to Protein Toxins and Their Use in Cell Biology. OUP / Sambrook and Tooze Publications, 1997, ISBN 978-0-191-54728-7 , p. 158.

[1] A. Bartok, A. Toth, S. Somodi, TG Szanto, P. Hajdu, G. Panyi, Z. Varga: Margatoxin is a non-selective inhibitor of human Kv1.3 K + channels. In: Toxicon: official journal of the International Society on Toxinology. Volume 87, September 2014, pp. 6-16, doi : 10.1016 / j.toxicon.2014.05.002 , PMID 24878374 .

[Rappuoli-2] Rino Rappuoli: Guidebook to Protein Toxins and Their Use in Cell Biology. OUP / Sambrook and Tooze Publications, 1997, ISBN 978-0-191-54728-7 , p. 158.