MAGE-A3
| MAGE-A3 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 34,807 Da / 314 amino acids | |
| Identifier | ||
| Gene name | MAGEA3 | |
| External IDs | ||
| Occurrence | ||
| Homology family | HOG000231161 | |
MAGE-A3 ( English melanoma antigen A3 ) is a human tumor antigen from the group of tumor-testis antigens .
properties
MAGE-A3 is 314 amino acids in length and 34,807 Da in mass . It comes as a tumor antigen not in healthy cells before (except in immune privileged spermatocytes ), but often in different tumors expressing such. B. melanomas , brain tumors , breast cancer , non-small cell lung tumors , ovarian cancer . It is therefore a target antigen in the development of cancer vaccines and cancer immunotherapies with adoptive cell transfer .
Individual evidence
- ↑ A. Esfandiary, S. Ghafouri-Fard: MAGE-A3: an immunogenic target used in clinical practice. In: Immunotherapy. Volume 7, number 6, 2015, pp. 683-704, doi: 10.2217 / imt.15.29 , PMID 26100270 .
- ↑ J. Domagala-Kulawik: The role of the immune system in non-small cell lung carcinoma and potential for therapeutic intervention. In: Translational lung cancer research. Volume 4, number 2, April 2015, pp. 177–190, doi: 10.3978 / j.issn.2218-6751.2015.01.11 , PMID 25870800 , PMC 4384216 (free full text).