MBDB
| Structural formula | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
||||||||||
| Structural formula without defined stereochemistry | ||||||||||
| General | ||||||||||
| Surname | MBDB | |||||||||
| other names |
|
|||||||||
| Molecular formula | C 12 H 17 NO 2 | |||||||||
| Brief description |
white crystals |
|||||||||
| External identifiers / databases | ||||||||||
|
||||||||||
| properties | ||||||||||
| Molar mass | 207.3 g mol −1 | |||||||||
| Physical state |
firmly |
|||||||||
| Melting point |
156 ° C |
|||||||||
| safety instructions | ||||||||||
|
||||||||||
| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | ||||||||||
MBDB is the abbreviation for the chemical substance 2-methylamino-1- (3,4-methylenedioxyphenyl) butane. MBDB is a homologue of MDMA (ecstasy) and structurally an amphetamine ( 1-phenylpropan-2-amine ).
synthesis
MBDB was synthesized by David Nichols and Alexander Shulgin and examined by the latter for its psychoactivity . Shulgin named it methyl-J in his private, informal nomenclature . A possible synthetic route is described in PIHKAL . There the corresponding aryl butyl ketone is reductively aminated. This creates a racemate , i.e. a 1: 1 mixture of ( R ) - and ( S ) - N -methyl-1- (1,3-benzo-dioxol-5-yl) -2-butylamine.
( R ) - N -Methyl-1- (1,3-benzo-dioxol-5-yl) -2-butylamine
( S ) - N -Methyl-1- (1,3-benzo-dioxol-5-yl) -2-butylamine
-MBDB_Structural_Formula_V1.svg)
-MBDB_Structural_Formula_V1.svg)
Pharmacological properties
Pharmacokinetics
The effective dose is in the range of 180–210 mg, the duration of action is 4–6 hours, the effect sets in very quickly after 20–40 minutes.
effect
MBDB increases the serotonin concentration in the synaptic cleft. The exact mechanisms of action have not yet been clarified. The effect creates euphoric states with increased empathy . Therefore, MBDB was also used in psycholytic psychotherapy sessions. Its use is now prohibited. The empathogenic effect is not as pronounced as with MDMA .
hazards
Like many other psychoactive substances, MBDB also carries the risk of triggering a latent psychosis . The physical effects are an increase in heart rate and blood pressure. In addition, there is a loss of appetite and increased sweat production. The pupils dilate ( mydriasis ), jaw clamps ( trismus ) or teeth grinding ( bruxism ) can also occur. Dehydration of the body is classified as particularly dangerous .
There is insufficient knowledge about the neurotoxicity of MBDB. The dependency potential is classified as medium .
Antidotes for overdose
In the event of an overdose, detoxification with activated charcoal can be attempted. If there is circulatory dysregulation, alpha blockers and calcium antagonists should be administered. In hyperthermia physical cooling should be made.
Narcotics regulations
Since 1995 MBDB has been classified in Appendix I , BtMG in Germany as a narcotic and therefore neither marketable nor prescribable. As with BDB , however, it is only of minor importance as a drug .
further reading
- Alexander Shulgin, Ann Shulgin: PIHKAL - A Chemical Love Story Transform Press, ISBN 0-9630096-0-5
