Mahlon R. DeLong

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Mahlon Robert DeLong (* 1938 ) is an American neurologist and professor at the Medical School at Emory University . He made important advances in the research and treatment of Parkinson's disease , dystonia , tremor, and other neurological movement disorders.

biography

DeLong attended Harvard Medical School (MA 1966), completed his internship at Boston City Hospital and his residency at Johns Hopkins Hospital in Baltimore with a professional doctorate (MD) in 1976. In between, he was at the National Institute of Mental Health in Bethesda in 1971 . He was licensed as a neurologist in 1980 and did research at Johns Hopkins University . From 1990 he was at Emory University, where he has been William Patterson Timmie Professor of Neurology since 1993 . He is a member of the Dana Alliance for Brain Initiative .

In 1971, together with Russell T. Richardson, in experiments with monkeys, he was the first to identify groups of neurons (in the nucleus basalis ) that are involved in the development of conditioned learning and they uncovered the role that the neurotransmitter acetylcholine plays in this. Afterwards, the release of acetylcholine from the basal ganglia into large areas of the neocortex leads to easier stimulation of nerve cells in the neocortex and easier formation of neural network connections.

DeLong pioneered the development of deep brain stimulation (DBS) for patients with advanced Parkinson's disease and other motor disorders. Electrodes are implanted in selected deeper brain areas (in Parkinson's disease, to the basal ganglia ) and these are stimulated externally, as in pacemakers, or their function is modulated. The procedure was first used for Parkinson's and movement disorders, but was then expanded to include psychological disorders such as depression , obsessive-compulsive disorder and Tourette's syndrome , for example .

In 2014 he received the Breakthrough Prize in Life Sciences for describing the dysfunctional circuits in Parkinson's disease and thus laying the foundations for deep brain stimulation and the Lasker ~ DeBakey Clinical Medical Research Award .

He is a member of the Institute of Medicine and the American Academy of Arts and Sciences (2009). DeLong received the Fred Springer Award from the American Parkinson's Disease Foundation and delivered the Schneider Lecture of the American Association of Neurological Surgeons (1999).

Fonts

  • Activity of pallidal neurons during movement , J. Neurophysiology, Volume 34, 1971, pp. 414-427
  • with RT Richardson Electrophysiological studies of the function of the nucleus basalis in primates . In TC Napier P. Kalivias, I. Hamin (editor), The Basal Forebrain: Anatomy to Function , Advances in Experimental Medicine and Biology, Vol. 295, 1991, pp. 232-252
  • with RT Richardson Functional implications of tonic and phasic activity changes in nucleus basalis neurons , in RT Richardson (Ed.) Activation To Acquisition: Functional Aspects Of The Basal Forebrain Cholinergic System , Birkhäuser 1991, pp 135-166
  • with GE Alexander, MD Crutcher, SJ Mitchell, RT Richardson Role of basal ganglia in limb movements , Human Neurobiology, Volume 2, 1984, pp. 235-244
  • Motor Subcircuits Mediating the Control of Movement Velocity: A PET Study , Journal of Neurophysiology, Volume 80, 1998, pp. 2162-2178
  • Neuronal Activity in the Basal Ganglia in Patients with Generalized Dystonia and Hemiballimus , Annals of Neurology, Volume 46, 1999, pp. 22-35
  • Reversal of Experimental Parkinsonism by Lesions of the Subthalamic Nucleus , Science, Volume 249, 1990, pp. 1436-1438
  • Editor with Ann M. Graybiel , Stephen T. Kitai Basal Ganglia VI , Kluwer 2003 (6th International Basal Ganglia Symposium, Brewster / Massachusetts 1998)
  • Editor with Noriichi Mano, Ikuma Hamada: Role of the cerebellum and basal ganglia in voluntary movement: proceedings of the 8th Tokyo Metropolitan Institute for Neuroscience (Tokyo 1992), Amsterdam: Excerpta Medica 1993

Web links

Individual evidence

  1. ↑ Both at the National Institute of Mental Health, later at Johns Hopkins University
  2. ↑ z. B. Timeline Behaviorist Approach, Matt Jarvis, Psychology Review, pdf .
  3. ^ DeLong Using Deep Brain Stimulation on the Mind: Handle with Care , Cerebrum, 2009
personal data
SURNAME DeLong, Mahlon R.
ALTERNATIVE NAMES DeLong, Mahlon Robert
BRIEF DESCRIPTION American neurologist
DATE OF BIRTH 1938