Margaret Buckingham
Margaret Buckingham (born March 2, 1945 ) is a British-French developmental biologist and professor at the Pasteur Institute in Paris.
Life
Buckingham studied biology at Oxford University , where she received her PhD in 1971. Her dissertation was on the modification of histones . In 1971 she went to Paris to the Pasteur Institute in the group of François Gros , where she dealt with the regulation of m-RNA in the differentiation of skeletal muscles. She has been researching for the CNRS since 1975 as a group leader and later became research director there. Since 1992 she has been a professor at the Pasteur Institute. From 1987 to 2010 she headed the Laboratory for Molecular Genetics Development there. She also headed the Molecular Biology Department from 1990 to 1994 and the Developmental Biology Department from 2002 to 2006.
In addition to the British, she has French citizenship. She is Scottish.
plant
Using molecular biology methods, Buckingham investigates how the processes of differentiation and renewal of tissue cells work, using mouse skeletal and cardiac muscle cells as a study subject. In particular, she investigates the role of transcription factors ( Pax , Foxc, Pitx, MRF ). She identified Pax3 and Pax7 as essential factors in the differentiation of muscle stem cells into muscle cells. In 2005 she discovered the existence of stem cells ( myoblasts ), so-called satellite cells , in adult muscle tissue, which are activated for the regeneration of muscle tissue, and Buckingham also investigated the role of the various transcription factors here.
In addition to the already known one, she identified a second heart field as a source of myocardial stem cells with two corresponding stem cell lines. She is also studying the morphogenesis of the heart in the embryo.
Awards and memberships
In 2013 she received the gold medal of the CNRS after receiving the silver medal in 1999. She is a member of the Académie des sciences , an external member of the National Academy of Sciences (2011), a member of the Academia Europaea (1998), the Royal Society (2013) and a fellow of the EMBO . She received the Prix Jaffé of the Académie des Sciences in 1990 and the Lifetime Achievement Award of the American Society for Developmental Biology in 2010. In 2002 she became a Knight of the Legion of Honor and in 2008 an officer of the Ordre national du Mérite .
From 2006 to 2012 she was President of the Société Française de Biologie du Développement (SFBD).
Web links
- Biography on the occasion of receiving the CNRS gold medal
- Brief biography
- Interview, Development 2011
- Literature by and about Margaret Buckingham in the SUDOC catalog (Association of French University Libraries)
Individual evidence
| personal data | |
|---|---|
| SURNAME | Buckingham, Margaret |
| ALTERNATIVE NAMES | Buckingham, Margaret E. |
| BRIEF DESCRIPTION | British-French developmental biologist |
| DATE OF BIRTH | March 2, 1945 |