Myelin Gene Regulatory Factor
| Myelin Gene Regulatory Factor | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 1138 amino acids (mouse);
1151 amino acids (human) |
|
| Isoforms | 2 | |
| Identifier | ||
| Gene names | MRF ; GM98; C11orf9 | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | multicellular animals | |
Myelin Gene Regulatory Factor ( MRF ) is a transcription factor , which in vertebrate animals , the gene expression of myelin - proteins in the central nervous system regulated. In addition to this essential role in myelination , MRF is also important for oligodendrocyte maturation and the maintenance of a differentiated cell status.
MRF has a region of high homology to the transcription factor Ndt80 of the yeast Saccharomyces cerevisiae (more precisely: the gene segments are orthologous to one another). This finding led to the assumption that it is itself a nuclear transcription factor.
The expression of MRF is specific for differentiated, myelinating oligodendrocytes in the central nervous system . It is essential for the homeostasis of myelin . As a result of a loss of functional MRF, there is a drastic decrease in the gene expression of important myelin components, such as: B. proteolipid protein (PLP), myelin basic protein (MBP), myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (MOG).
MRF is thus one of the key components in the activation and regulation of the transcription of myelin proteins.
Individual evidence
- ↑ InterPro : IPR025719 Myelin gene regulatory factor C-terminal domain (English)
- ↑ Helena Bujalka, Matthias Koenning u. a .: MYRF Is a Membrane-Associated Transcription Factor That Autoproteolytically Cleaves to Directly Activate Myelin Genes. In: PLoS Biology. 11, 2013, p. E1001625, doi : 10.1371 / journal.pbio.1001625 .
- ↑ Matthias Koenning, Jackson, Stacey Hay, Curtis M. Faux, Clare Kilpatrick, Trevor J. Willingham, Melanie Emery, Ben: Myelin Gene Regulatory Factor Is Required for Maintenance of myelin and Mature Oligodendrocyte Identity in the adult CNS . In: The Journal of Neuroscience . 32, No. 36, September 5, 2012, pp. 12528-12542. doi : 10.1523 / jneurosci.1069-12.2012 .
- ↑ MRF ( english ) 13. Accessed October 14, 2013.
- ^ H. Senoo, HY Wang, T. Araki, JG Williams, M. Fukuzawa: An orthologue of the myelin-gene Regulatory Transcription Factor regulates Dictyostelium prestalk differentiation. In: The International journal of developmental biology. Volume 56, number 5, 2012, pp. 325-332, doi : 10.1387 / ijdb.120030jw , PMID 22811266 , PMC 3586673 (free full text).
- ↑ Matthias Koenning, Jackson, Stacey Hay, Curtis M. Faux, Clare Kilpatrick, Trevor J. Willingham, Melanie Emery, Ben: Myelin Gene Regulatory Factor Is Required for Maintenance of myelin and Mature Oligodendrocyte Identity in the adult CNS . In: The Journal of Neuroscience . 32, No. 36, September 5, 2012, pp. 12528-12542. doi : 10.1523 / jneurosci.1069-12.2012 .