Marguerite Vogt

Marguerite Vogt (born February 13, 1913 in Berlin , † July 6, 2007 in La Jolla , California ) was a cancer researcher and virologist . She became known for her research in the field of poliomyelitis and her cancer research at the Salk Institute for Biological Studies .

Life

Marguerite Vogt was the youngest daughter of Oskar Vogt and Cécile Vogt-Mugnier, who was born in France . In 1937 Marguerite Vogt received her doctorate in medicine from the University of Berlin . Her parents were both recognized neurologists , so she grew up in an extremely scientific environment. Vogt's older sister, Marthe Louise Vogt (1903-2003) was a neuropharmacologist who became a member of the Royal Society and a professor at Cambridge.

Career

Marguerite Vogt joined her parents in their private institute for brain research and general biology in Neustadt , where the family lived during World War II . There she dealt intensively with the development of Drosophila . She has published more than 30 papers on the ring gland and homeotic mutants.

Marguerite Vogt moved to the California Institute of Technology in 1950 to work with Max Delbrück . He introduced her to Renato Dulbecco , a junior faculty member in the field of biology . Vogt and Dulbecco worked together on methods to cultivate the poliovirus . They were the first to successfully grow the virus in vitro . This was an important step in order to subsequently be able to produce a vaccine. Vogt's technical skills as a cell breeder were crucial in this work. They then directed their research into the field of cancer-causing viruses, including the polyoma virus. They managed to cultivate this virus and check the dormancy of the virus.

Dulbecco was recruited for the newly founded Salk Institute for Biological Studies in 1963 . Vogt followed him as a research fellow. They continued their work on tumor-causing viruses. However, their interests increasingly diverged. In 1973, Vogt was appointed professor, which was an independent position that allowed her to pursue her own goals regarding the origins of cancer. Vogt's research developed towards the investigation of cellular immortalization in cancer cells and the role of telomeres in this process. She published her last essay in 1998.

Marguerite Vogt made significant contributions in many areas: as a Drosophila developmental geneticist , as a virologist who worked with Nobel Prize winner Renato Dulbecco, and as a researcher in the fields of viral transformation and cellular immortalization. In addition, Vogt was an influential mentor and colleague to numerous young academics, including some future Nobel Prize winners. Her work has never been recognized by a significant award, although this is largely viewed as a failure. She was known for her commitment and she was still working in her laboratory when she was over 80 years old.

Marguerite Vogt died on July 6, 2007 at her home in La Jolla , California.

Web links

• Remembering Marguerite Vogt: a Biography
• Report about Vogt in the magazine "Insidesalk" November 2007 (PDF; 2.5 MB)

Individual evidence

1. ↑ http://www.oac.cdlib.org/findaid/ark:/13030/kt3b69r5x0/admin/
2. ↑ ^{a b c d e f} Natalie Angier: SCIENTIST AT WORK - Marguerite Vogt; A Lifetime Later, Still in Love With the Lab. , The New York Times. April 10, 2001, p. D1. 
3. ↑ ^{a b c d e f} M. Haas , EB Lewis: Cover Legend . In: Cancer Research . 58, No. 22, 1998, pp. Ix.
4. ↑ ^{a b c} Susan Forsburg: Remembering Marguerite Vogt . Retrieved March 10, 2012.
5. ^ Davy Jones: Marguerite Vogt Tribute Site . Retrieved July 20, 2007.
6. ↑ ^{a b c} Interview with Renato Dulbecco: Caltech Oral History . Retrieved July 20, 2007.
7. ↑ Longtime Salk Researcher Marguerite Vogt Dies . ( Memento of the original from September 9, 2007 in the Internet Archive ) Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice. The Salk Institute, July 6, 2007.