Masakatsu Shibasaki

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Masakatsu Shibasaki ( Japanese 柴 崎 正 勝 , Shibasaki Masakatsu ; born January 25, 1947 in Saitama Prefecture , Japan ) is a Japanese chemist .

Life

Shibasaki studied chemistry at the University of Tokyo , where he received his PhD in 1974 in the group of Shun'ichi Yamada . After a post-doctoral stay with EJ Corey at Harvard University , he returned to Japan in 1977, where he accepted a position at Teikyō University . In 1983 he became group leader at the Sagami Chemical Research Center, in 1986 he became a professor at Hokkaidō University . In 1991 he accepted a professorship at the University of Tokyo. Since 2010 Shibasaki has been director at MCRF (Microbial Chemistry Research Center) in Tokyo.

In 1995 he was visiting professor at the Philipps University in Marburg .

His research focuses on asymmetric catalysis and the medicinal chemistry of biologically significant components. The Hirsch factor of Masakatsu Shibasaki 73, which marks his outstanding scientific achievements clearly.

Shibasaki synthesis

In 2006 Shibasaki published a novel synthesis of Tamiflu bypassing shikimic acid

Shibasaki Tamiflu Synthesis Part I Shibasaki Tamiflu Synthesis Part II
Shibasaki Tamiflu Synthesis Part I Part II

Honors

Shibasaki received the Pharmaceutical Society of Japan Prize for Young Scientists in 1981. In 1994 he received the Inoue Prize for Science and in 1996 the Fluka Prize Reagent of the Year. In 1998 he was awarded the Elsevier Prize for Inventiveness in Organic Chemistry, a year later the Prize of the Pharmaceutical Society of Japan and the Prize for Molecular Chirality. The Naito Foundation awarded him the 2001 Research Prize, the American Chemical Society the Arthur C. Cope Senior Scholar Prize (2002). This was followed by awards with the Toray Science and Technology Prize (2004), the Japan Academy Prize (2005), the Sankyo Takamine Memorial Prize and the Shiokawa Prize (2006), the Centenary Medal and the Lectureship of the Royal Society of Chemistry (2007), the American Chemical Society's Prize for Creativity in Synthetic Organic Chemistry (2008) and the Prelog Medal of the ETH Zurich (2008).

He was elected a Fellow of the Royal Society of Chemistry in 1997 and an Honorary Fellow of the Chemical Research Society of India in 2003. Shibasaki is an honorary member of the Chemical Society of Japan.

Literature (selection)

Web links

Individual evidence

  1. Naoya Kumagai, Motomu Kanai and Hiroaki Sasai: A Career in Catalysis: Masakatsu Shibasaki , ACS Catal., 2016, 6, pp. 4699-4709, doi : 10.1021 / acscatal.6b01227 .
  2. Harald Gröger : Shibasaki Catalysts and Their Use for Asymmetric Synthetic Applications by the Chemical Industry , Eur. J. Org. Chem. 2016, pp. 4116-4123, doi : 10.1002 / ejoc.21600174 .
  3. Yuhei Fukuta, Tsuyoshi Mita, Nobuhisa Fukuda, Motomu Kanai and Masakatsu Shibasaki: De Novo Synthesis of Tamiflu via a Catalytic Asymmetric Ring-Opening of meso-Aziridines with TMSN3. In: Journal of the American Chemical Society . Volume 128, 2006, pp. 6312-6313, doi : 10.1021 / ja061696k .
  4. Tsuyoshi Mita, Nobuhisa Fukuda, Francesc X. Roca, Motomu Kanai and Masakatsu Shibasaki: Second Generation Catalytic Asymmetric Synthesis of Tamiflu: Allylic Substitution Route. In: Organic Letters . Volume 9, 2007, pp. 259-262, doi : 10.1021 / ol062663c .